4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert-butyl ester

Base Information

Chemical Name:4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert-butyl ester
CAS No.:1187851-74-6
Molecular Formula:C₁₆H₁₅ClF₃N₃O₂
Molecular Weight:373.762
Hs Code.:

Synonyms:4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert-butyl ester

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Chemical Property of 4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert-butyl ester

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Technology Process of 4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert-butyl ester

There total 1 articles about 4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 18144-47-3
tert-butyl 4-aminobenzoate

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1187851-74-6
4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert-butyl ester

Guidance literature:: 2,4-dichloro-5-trifluoromethylpyrimidine; With zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 0 ℃; for 1h;

tert-butyl 4-aminobenzoate; With triethylamine; In 1,2-dichloro-ethane; tert-butyl alcohol; for 1.5h;

Reference yield: 73.0%

: 1187851-74-6
4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert-butyl ester

: 771573-22-9
1-[3-(methylsulfonyl)phenyl]methanamine

: C₂₀H₁₇F₃N₄O₄S

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tert-butyl alcohol; at 80 ℃; for 24h;

Reference yield:

: 1187851-74-6
4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert-butyl ester

: 878156-22-0
2-(4-carboxy-phenylamino)-4-chloro-5-trifluoromethyl-pyrimidine

Guidance literature:: 4-(4-chloro-5-trifluoromethyl-pyrimidin-2-ylamino)-benzoic acid tert-butyl ester; With thionyl chloride; In acetonitrile; at 70 ℃;

With water; In acetonitrile; at 70 ℃;