7-bromo-1’-(3,4-difluorobenzyl)-3-(4-methoxyphenyl)-spiro[benzo[e][1,3]oxazine-2,4’-piperidin]-4(3H)-one

Base Information

Chemical Name:7-bromo-1’-(3,4-difluorobenzyl)-3-(4-methoxyphenyl)-spiro[benzo[e][1,3]oxazine-2,4’-piperidin]-4(3H)-one
CAS No.:1620884-98-1
Molecular Formula:C₂₆H₂₃BrF₂N₂O₃
Molecular Weight:529.381
Hs Code.:

Synonyms:7-bromo-1’-(3,4-difluorobenzyl)-3-(4-methoxyphenyl)-spiro[benzo[e][1,3]oxazine-2,4’-piperidin]-4(3H)-one

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Chemical Property of 7-bromo-1’-(3,4-difluorobenzyl)-3-(4-methoxyphenyl)-spiro[benzo[e][1,3]oxazine-2,4’-piperidin]-4(3H)-one

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Technology Process of 7-bromo-1’-(3,4-difluorobenzyl)-3-(4-methoxyphenyl)-spiro[benzo[e][1,3]oxazine-2,4’-piperidin]-4(3H)-one

There total 3 articles about 7-bromo-1’-(3,4-difluorobenzyl)-3-(4-methoxyphenyl)-spiro[benzo[e][1,3]oxazine-2,4’-piperidin]-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1620885-46-2
7-bromo-1‘-(3,4-difluorobenzyl)-spiro[benzo[e][1,3]oxazine-2,4’-piperidin]-4(3H)-one

: 5720-07-0
4-methoxyphenylboronic acid

: 1620884-98-1
7-bromo-1’-(3,4-difluorobenzyl)-3-(4-methoxyphenyl)-spiro[benzo[e][1,3]oxazine-2,4’-piperidin]-4(3H)-one

Guidance literature:: With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; Molecular sieve;

Reference yield:

: 5428-40-0
4-bromo-2-hydroxybenzamide

: 1620884-98-1
7-bromo-1’-(3,4-difluorobenzyl)-3-(4-methoxyphenyl)-spiro[benzo[e][1,3]oxazine-2,4’-piperidin]-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: p-toluenesulfonic acid monohydrate / toluene / 4 h / 140 °C

2: triethylamine; copper diacetate / dichloromethane / 20 °C / Molecular sieve

With p-toluenesulfonic acid monohydrate; copper diacetate; triethylamine; In dichloromethane; toluene;

Reference yield:

: 22717-56-2
4-bromo-2-Hydroxybenzoic Acid Methylester

: 1620884-98-1
7-bromo-1’-(3,4-difluorobenzyl)-3-(4-methoxyphenyl)-spiro[benzo[e][1,3]oxazine-2,4’-piperidin]-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide / isopropyl alcohol / 20 °C / Inert atmosphere

2: p-toluenesulfonic acid monohydrate / toluene / 4 h / 140 °C

3: triethylamine; copper diacetate / dichloromethane / 20 °C / Molecular sieve

With ammonium hydroxide; p-toluenesulfonic acid monohydrate; copper diacetate; triethylamine; In dichloromethane; isopropyl alcohol; toluene;