(S)-benzyl (1-(5-iodo-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Base Information

Chemical Name:(S)-benzyl (1-(5-iodo-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate
CAS No.:1609191-08-3
Molecular Formula:C₁₉H₂₅IN₄O₃
Molecular Weight:484.337
Hs Code.:

Synonyms:(S)-benzyl (1-(5-iodo-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

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Chemical Property of (S)-benzyl (1-(5-iodo-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

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Technology Process of (S)-benzyl (1-(5-iodo-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

There total 9 articles about (S)-benzyl (1-(5-iodo-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-(1-(((benzyloxy)carbonyl)amino)-6-carboxyhexyl)-5-iodo-1H-imidazol-3-ium trifluoroacetate

: 74-89-5
methylamine

: 1609191-08-3
(S)-benzyl (1-(5-iodo-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: (S)-7-(((benzyloxy)carbonyl)amino)-7-(5-iodo-1H-imidazol-2-yl)heptanoic acid

: 74-89-5
methylamine

: 1609191-08-3
(S)-benzyl (1-(5-iodo-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/acsmedchemlett.5b00468

Reference yield:

: 1609191-03-8
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-8-oxooctanoate

: 1609191-08-3
(S)-benzyl (1-(5-iodo-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia / methanol / 72 h / 20 °C / Sealed tube

2: N-iodo-succinimide / acetonitrile / 2 h / -10 °C

3: sodium sulfite; tetrabutylammonium dihydrogen phosphate / water; 1,4-dioxane / 0.5 h / 160 °C / Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 2.5 h / 0 - 20 °C

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 20 °C

With N-iodo-succinimide; ammonia; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; tetrabutylammonium dihydrogen phosphate; trifluoroacetic acid; sodium sulfite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;