diphenyl [(diethoxythiophosphorylamino)(p-tolyl)methyl]phosphonate

Base Information

• Chemical Name: diphenyl [(diethoxythiophosphorylamino)(p-tolyl)methyl]phosphonate
• CAS No.: 110814-37-4
• Molecular Formula: C₂₄H₂₉NO₅P₂S
• Molecular Weight: 505.511
• Mol file: 110814-37-4.mol

Synonyms:diphenyl [(diethoxythiophosphorylamino)(p-tolyl)methyl]phosphonate

Chemical Property of diphenyl [(diethoxythiophosphorylamino)(p-tolyl)methyl]phosphonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of diphenyl [(diethoxythiophosphorylamino)(p-tolyl)methyl]phosphonate

There total 2 articles about diphenyl [(diethoxythiophosphorylamino)(p-tolyl)methyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

O,O-diethyl phosphoramidothioate (17321-48-1) + Diphenyl phosphorochloridite (5382-00-3) + 4-methyl-benzaldehyde (104-87-0) → diphenyl [(diethoxythiophosphorylamino)(p-tolyl)methyl]phosphonate (110814-37-4)

Guidance literature:

With zinc(II) chloride; In dichloromethane; 1.) room temp., 0.5 h, 2.) 40 deg C, 6 h;

DOI:10.1055/s-1988-27610

Reference yield: 90.0%

triphenyl phosphite (101-02-0) + O,O-diethyl phosphoramidothioate (17321-48-1) + 4-methyl-benzaldehyde (104-87-0) → diphenyl [(diethoxythiophosphorylamino)(p-tolyl)methyl]phosphonate (110814-37-4)

Guidance literature:

With acetyl chloride; at 20 ℃;

DOI:10.1016/j.bioorg.2006.05.003

Reference yield: 90.0%

diphenyl [(diethoxythiophosphorylamino)(p-tolyl)methyl]phosphonate (110814-37-4) → diphenyl [(amino)(p-tolyl)methyl]phosphonate hydrobromide (106807-00-5)

Guidance literature:

With hydrogen bromide; In acetic acid; for 0.5h; Ambient temperature;

DOI:10.1055/s-1986-31790

upstream raw materials:

triphenyl phosphite

O,O-diethyl phosphoramidothioate

4-methyl-benzaldehyde

Diphenyl phosphorochloridite

Downstream raw materials:

diphenyl [(amino)(p-tolyl)methyl]phosphonate hydrobromide