3-bromo-1-(3-chloropyridin-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:3-bromo-1-(3-chloropyridin-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-5-carboxamide
CAS No.:1410073-12-9
Molecular Formula:C₁₅H₉BrClN₅O₃
Molecular Weight:422.625
Hs Code.:

Synonyms:3-bromo-1-(3-chloropyridin-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-5-carboxamide

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Chemical Property of 3-bromo-1-(3-chloropyridin-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-5-carboxamide

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Technology Process of 3-bromo-1-(3-chloropyridin-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-5-carboxamide

There total 7 articles about 3-bromo-1-(3-chloropyridin-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 943982-60-3
3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride

: 100-01-6,104810-17-5
4-nitro-aniline

: 1410073-12-9
3-bromo-1-(3-chloropyridin-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Cooling with ice;
DOI:10.1016/j.tet.2015.01.059

Reference yield:

: 500011-86-9
3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid

: 1410073-12-9
3-bromo-1-(3-chloropyridin-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 12.33 h / 20 °C / Cooling with ice

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.3390/molecules170910414

Reference yield:

: 2402-77-9
2,3-dichloro-pyridine

: 1410073-12-9
3-bromo-1-(3-chloropyridin-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrazine hydrate / ethanol / 36 h / Reflux

2.1: sodium ethanolate / ethanol / 0.17 h / Reflux

2.2: 0.5 h / Reflux

3.1: phosphorus(V) oxybromide / acetonitrile / 5 h / Reflux

4.1: sulfuric acid; dipotassium peroxodisulfate / acetonitrile / 4.5 h / Reflux

5.1: sodium hydroxide; water / methanol / 6 h / 20 °C

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12.33 h / 20 °C / Cooling with ice

With dipotassium peroxodisulfate; oxalyl dichloride; hydrazine hydrate; sulfuric acid; water; sodium ethanolate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; phosphorus(V) oxybromide; In methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.3390/molecules170910414