2-methyl-6-[4,4-dimethyl-1-(6-methylpyridin-2-yl)-1-phenylpenta-1,2-dien-3-yl]pyridine

Base Information

Chemical Name:2-methyl-6-[4,4-dimethyl-1-(6-methylpyridin-2-yl)-1-phenylpenta-1,2-dien-3-yl]pyridine
CAS No.:1141551-29-2
Molecular Formula:C₂₅H₂₆N₂
Molecular Weight:354.495
Hs Code.:

Synonyms:2-methyl-6-[4,4-dimethyl-1-(6-methylpyridin-2-yl)-1-phenylpenta-1,2-dien-3-yl]pyridine

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Chemical Property of 2-methyl-6-[4,4-dimethyl-1-(6-methylpyridin-2-yl)-1-phenylpenta-1,2-dien-3-yl]pyridine

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Technology Process of 2-methyl-6-[4,4-dimethyl-1-(6-methylpyridin-2-yl)-1-phenylpenta-1,2-dien-3-yl]pyridine

There total 9 articles about 2-methyl-6-[4,4-dimethyl-1-(6-methylpyridin-2-yl)-1-phenylpenta-1,2-dien-3-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1141551-77-0
C₂₃H₂₀N₂O₂

: 594-19-4
tert.-butyl lithium

: 1141551-29-2
2-methyl-6-[4,4-dimethyl-1-(6-methylpyridin-2-yl)-1-phenylpenta-1,2-dien-3-yl]pyridine

Guidance literature:: tert.-butyl lithium; With CuCN; In tetrahydrofuran; pentane; at -40 ℃;

C₂₃H₂₀N₂O₂; In tetrahydrofuran; pentane; at -80 ℃; Further stages.;
DOI:10.1002/ejic.200701049

Reference yield: 30.0%

: C₂₆H₂₆N₂O₂

: 100-58-3
phenylmagnesium bromide

: 1141551-29-2
2-methyl-6-[4,4-dimethyl-1-(6-methylpyridin-2-yl)-1-phenylpenta-1,2-dien-3-yl]pyridine

Guidance literature:: phenylmagnesium bromide; With zinc dibromide; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 0.75h; Inert atmosphere;

C₂₆H₂₆N₂O₂; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/d0dt00665c

Reference yield:

: 5315-25-3
2-bromo-6-methylpyridine

: 1141551-29-2
2-methyl-6-[4,4-dimethyl-1-(6-methylpyridin-2-yl)-1-phenylpenta-1,2-dien-3-yl]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Reflux

3.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 5 h / 20 °C / Inert atmosphere

4.1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: zinc dibromide / diethyl ether; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.2: 0.5 h / 0 °C / Inert atmosphere

With dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; triethylamine; zinc dibromide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1039/d1dt02929k