TC-N 1752

Base Information

• Chemical Name: TC-N 1752
• CAS No.: 1211866-85-1
• Molecular Formula: C₂₅H₂₇F₃N₆O₃
• Molecular Weight: 516.523
• Mol file: 1211866-85-1.mol

Synonyms:N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

Chemical Property of TC-N 1752

Chemical Property:

• PKA: 14.80±0.70(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)

Purity/Quality:

≥99% by HPLC ^*data from raw suppliers

TC-N 1752 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: TC-N 1752 is a potent, state-dependent inhibitor of Nav1.7, which is a neuronal voltage gated sodium channel and a critical mediator of pain sensitization.

Technology Process of TC-N 1752

There total 5 articles about TC-N 1752 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-(3-(4-chloro-1,3,5-triazin-2-ylamino)-2-methylphenyl)acetamide (1211876-60-6) + 4-(4-(trifluoromethoxy)benzyloxy)piperidine trifluoroacetate salt (1211875-20-5) → N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide (1211866-85-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Cooling with ice;

DOI:10.1021/jm200018k

Reference yield:

N-(3-amino-2-methylphenyl)acetamide (65999-76-0) → N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide (1211866-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C / Cooling with ice

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm200018k

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide (1211866-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Cooling with ice

1.2: 15 h / 20 °C / Cooling with ice

2.1: dichloromethane / 20 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C / Cooling with ice

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jm200018k

upstream raw materials:

N-(3-(4-chloro-1,3,5-triazin-2-ylamino)-2-methylphenyl)acetamide

4-(4-(trifluoromethoxy)benzyloxy)piperidine trifluoroacetate salt

4-[(4-trifluoromethoxy)phenyl]methoxypiperidine-1-formic acid tert-butyl ester

4-trifluoromethoxybenzyl bromide

Refernces