3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-mercapto-5-nitro-benzaldehyde

Base Information

Chemical Name:3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-mercapto-5-nitro-benzaldehyde
CAS No.:288852-86-8
Molecular Formula:C₁₆H₂₄N₂O₅S
Molecular Weight:356.443
Hs Code.:

Synonyms:3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-mercapto-5-nitro-benzaldehyde

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Chemical Property of 3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-mercapto-5-nitro-benzaldehyde

Chemical Property:

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Technology Process of 3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-mercapto-5-nitro-benzaldehyde

There total 5 articles about 3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-mercapto-5-nitro-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288852-85-7
dimethyl-thiocarbamic acid S-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester

: 288852-86-8
3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-mercapto-5-nitro-benzaldehyde

Guidance literature:: With potassium hydroxide; water; In ethanol;
DOI:10.1039/a903877i

Reference yield:

: 288852-82-4
N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine

: 288852-86-8
3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-mercapto-5-nitro-benzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / p-toluenesulfonic acid; hydrogen / Pd/C / ethanol / 6 h / 120 °C / 5700.38 Torr

2: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C

3: triethylamine / dimethylformamide / 15 h / 0 - 20 °C

4: toluene / 6 h / Heating

5: potassium hydroxide / ethanol; H₂O / 2 h / 20 °C

With potassium hydroxide; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; 1: Hydrogenolysis / 2: Alkylation / 3: Substitution / 4: Isomerization / 5: Hydrolysis;
DOI:10.1021/jo000175r

Reference yield:

: 288852-83-5
3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-hydroxy-5-nitro-benzaldehyde

: 288852-86-8
3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-mercapto-5-nitro-benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dimethylformamide / 15 h / 0 - 20 °C

2: toluene / 6 h / Heating

3: potassium hydroxide / ethanol; H₂O / 2 h / 20 °C

With potassium hydroxide; triethylamine; In ethanol; water; N,N-dimethyl-formamide; toluene; 1: Substitution / 2: Isomerization / 3: Hydrolysis;
DOI:10.1021/jo000175r