N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine

Base Information

• Chemical Name: N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine
• CAS No.: 288852-82-4
• Molecular Formula: C₁₅H₂₅NO₂
• Molecular Weight: 251.369
• Mol file: 288852-82-4.mol

Synonyms:N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine

Chemical Property of N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine

There total 1 articles about N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromoethyl ethyl ether (592-55-2) + benzylamine (100-46-9) → N-benzyl-2-ethoxyethanamine (67411-38-5) + N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine (288852-82-4)

Guidance literature:

With potassium carbonate; at 80 ℃; for 1h; Inert atmosphere; neat (no solvent);

DOI:10.1039/c2cc31394d

Reference yield: 71.0%

N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine (288852-82-4) → bis-(2-ethoxyethyl)amine (124-21-0)

Guidance literature:

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; at 120 ℃; for 6h; under 5700.38 Torr;

DOI:10.1021/jo000175r

Reference yield:

N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine (288852-82-4) → dimethyl-thiocarbamic acid O-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester (288852-84-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / p-toluenesulfonic acid; hydrogen / Pd/C / ethanol / 6 h / 120 °C / 5700.38 Torr

2: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C

3: triethylamine / dimethylformamide / 15 h / 0 - 20 °C

With hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1: Hydrogenolysis / 2: Alkylation / 3: Substitution;

DOI:10.1021/jo000175r

upstream raw materials:

2-Bromoethyl ethyl ether

benzylamine

Downstream raw materials:

bis-(2-ethoxyethyl)amine

3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-mercapto-5-nitro-benzaldehyde

3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-hydroxy-5-nitro-benzaldehyde

dimethyl-thiocarbamic acid S-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester