tert-butyl N-((tert-butoxy)carbonyl)-(5-amino-2-fluorophenyl)carbamate

Base Information

• Chemical Name: tert-butyl N-((tert-butoxy)carbonyl)-(5-amino-2-fluorophenyl)carbamate
• CAS No.: 1125632-87-2
• Molecular Formula: C₁₆H₂₃FN₂O₄
• Molecular Weight: 326.368

Synonyms:tert-butyl N-((tert-butoxy)carbonyl)-(5-amino-2-fluorophenyl)carbamate

Chemical Property of tert-butyl N-((tert-butoxy)carbonyl)-(5-amino-2-fluorophenyl)carbamate

Chemical Property:

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Technology Process of tert-butyl N-((tert-butoxy)carbonyl)-(5-amino-2-fluorophenyl)carbamate

There total 7 articles about tert-butyl N-((tert-butoxy)carbonyl)-(5-amino-2-fluorophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

→ tert-butyl N-((tert-butoxy)carbonyl)-(5-amino-2-fluorophenyl)carbamate (1125632-87-2)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; at 20 ℃;

Reference yield: 64.0%

tert-butyl-N-((tert-butoxy)carbonyl)-N-(2-fluoro-5-nitrophenyl)carbamate (1125632-86-1) → tert-butyl N-((tert-butoxy)carbonyl)-(5-amino-2-fluorophenyl)carbamate (1125632-87-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃;

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-((tert-butoxy)carbonyl)-(5-amino-2-fluorophenyl)carbamate (1125632-87-2) + tert-butyl (5-amino-2-fluorophenyl)carbamate (535170-18-4)

Guidance literature:

2-chloro-5-nitropyridine; di-tert-butyl dicarbonate; at 80 ℃; for 24h;

With 10% Pd/C; hydrogen; In tetrahydrofuran; ethanol; at 20 ℃; for 24h; under 760.051 Torr;

DOI:10.1016/j.bmc.2012.07.032

upstream raw materials:

di-tert-butyl dicarbonate

6-fluoro-3-nitroaniline

tert-butyl-N-((tert-butoxy)carbonyl)-N-(2-fluoro-5-nitrophenyl)carbamate

2-chloro-5-nitropyridine

Downstream raw materials:

N-(5-{[4-fluoro-3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thi azolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

N-{5-[(3-amino-4-fluorophenyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-4-fluorophenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

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