5-acetoxy-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)-1-nitroethyl>-1-ethenyl-1-methylcyclohexane

Base Information

Chemical Name:5-acetoxy-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)-1-nitroethyl>-1-ethenyl-1-methylcyclohexane
CAS No.:73719-52-5
Molecular Formula:C₂₃H₂₈N₂O₅
Molecular Weight:412.486
Hs Code.:

Synonyms:5-acetoxy-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)-1-nitroethyl>-1-ethenyl-1-methylcyclohexane

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Chemical Property of 5-acetoxy-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)-1-nitroethyl>-1-ethenyl-1-methylcyclohexane

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Technology Process of 5-acetoxy-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)-1-nitroethyl>-1-ethenyl-1-methylcyclohexane

There total 10 articles about 5-acetoxy-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)-1-nitroethyl>-1-ethenyl-1-methylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 56437-05-9
1-cyano-4-methoxybenzocyclobutane

: 74842-12-9
5-acetoxy-1-ethenyl-1-methyl-2-(1-nitroethenyl)cyclohexane

: 73719-52-5
5-acetoxy-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)-1-nitroethyl>-1-ethenyl-1-methylcyclohexane

Guidance literature:: With sodium amide; In tetrahydrofuran; ammonia; at -78 ℃; for 0.583333h;
DOI:10.1021/jo01310a026

Reference yield:

: 487-51-4
4-carbethoxy-3-methyl-2-cyclohexen-1-one

: 73719-52-5
5-acetoxy-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)-1-nitroethyl>-1-ethenyl-1-methylcyclohexane

Guidance literature:: Multi-step reaction with 9 steps

1: 65 percent / tetrahydrofuran / 0.5 h / -78 °C

2: 67 percent / lithium aluminum hydride / tetrahydrofuran / 1.) 0 deg C; 2.) room temp., 6 h

3: 82 percent / pyridine / 1.) 0 deg C; 2.) room temp., 6 h

4: 83 percent / pyridine / 10 h / Ambient temperature

5: 85 percent / sodium iodide / acetone / 10 h / Heating

6: 29 percent / sodium nitrite / dimethylformamide / 15 h / 80 °C

8: 73 percent / hydrogen chloride / benzene / 10 h / Heating

9: 62 percent / sodium amide / liquid ammonia; tetrahydrofuran / 0.58 h / -78 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium amide; sodium iodide; sodium nitrite; In tetrahydrofuran; pyridine; ammonia; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo01310a026

Reference yield:

: 74842-04-9
1-ethenyl-5-hydroxy-2-(hydroxymethyl)-1-methylcyclohexane

: 73719-52-5
5-acetoxy-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)-1-nitroethyl>-1-ethenyl-1-methylcyclohexane

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / pyridine / 1.) 0 deg C; 2.) room temp., 6 h

2: 83 percent / pyridine / 10 h / Ambient temperature

3: 85 percent / sodium iodide / acetone / 10 h / Heating

4: 29 percent / sodium nitrite / dimethylformamide / 15 h / 80 °C

6: 73 percent / hydrogen chloride / benzene / 10 h / Heating

7: 62 percent / sodium amide / liquid ammonia; tetrahydrofuran / 0.58 h / -78 °C

With hydrogenchloride; sodium amide; sodium iodide; sodium nitrite; In tetrahydrofuran; pyridine; ammonia; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo01310a026