56437-05-9

Basic information

• Product Name: Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 3-methoxy-
• Synonyms: 4-methoxybenzocyclobutane-1-carbonitrile;1,2-dihydroxy-4-methoxybenzocyclobutene-1-carbonitrile;4-methoxybenzocyclobutene-1-carbonitrile;1-cyano-4-methoxybenzocyclobutane
• CAS NO: 56437-05-9
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Mol File: 56437-05-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 58-60℃
• CAS DataBase Reference: Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 3-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 3-methoxy-(56437-05-9)
• EPA Substance Registry System: Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 3-methoxy-(56437-05-9)

Safety Data

• Hazardous Substances Data: 56437-05-9(Hazardous Substances Data)

Upstream product

• 100-84-5 1-methoxy-3-methyl-benzene 
• 19614-12-1 2-bromo-5-methoxybenzyl bromide 
• 591-31-1 3-methoxy-benzaldehyde 
• 100-83-4 meta-hydroxybenzaldehyde 
• 58986-30-4 α-cyano-β-(2-bromo-5-methoxyphenyl)propionic acid 
• 58986-29-1 3-(2-bromo-5-methoxyphenyl)-2-cyanoacrylic acid 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 84452-07-3 1-Dichloromethyl-4-methoxy-2-methyl-benzene 
• 60100-18-7 3-(2-bromo-5-methoxyphenyl)propanenitrile 

Downstream Products

• 96045-14-6 cis-1-cyano-2-(4-methoxyphenyl)-6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 73230-89-4 4-Acetoxy-1-ethenyl-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)ethyl>-1-methylcyclohexane 
• 73230-87-2 4-Acetoxy-1-ethenyl-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)-2-hydroxyethyl>-1-methylcyclohexane 
• 73719-52-5 5-acetoxy-2-<2-(1-cyano-4-methoxybenzocyclobutenyl)-1-nitroethyl>-1-ethenyl-1-methylcyclohexane 
• 242473-46-7 3-hydroxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile 
• 1359668-73-7 {3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-trien-7-yl}acetic acid 
• 1359668-71-5 3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid 
• 1359669-55-8 {3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-trien-7-yl}acetonitrile 
• 1359669-53-6 {3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl-4-methylbenzenesulfonate 
• 1359669-51-4 {3-[(2',6'-dimethylbiphenyl-3-yl)methoxy]bicyclo[4.2.0]octa-1,3,5-trien-7-yl}methanol 
• 128333-14-2 1,2-Dihydro-4-methoxybenzocyclobuten-1-yl 2-phenylthiopropan-2-yl ketone 
• 128333-21-1 1,2-Dihydro-4-methoxy-1-(3-methyl-3-phenylthiobut-1-en-2-yl)benzocyclobutene 
• 128333-16-4 1,2-Dihydro-4-methoxybenzocyclobuten-1-yl phenyl ketone 
• 128333-12-0 Cyclohexyl 1,2-dihydro-4-methoxybenzocyclobuten-1-yl ketone 

Relevant articles and documents

On the influence of the nature of the iron(III) salt catalyst precursor for the preparation of sodium amide

Our recent experiments, for the formation of sodium amide from liquid ammonia and sodium metal, revealed the necessity to employ Fe(NO 3)3?9H2O as the catalyst precursor, and not FeCl3. In the presence of FeCl3, we observed several times the ignition of the mixture during the hydrolysis, and the desired product was not obtained.

Total synthesis of cortistatins A and J

This paper describes the details of our synthetic studies on the marine steroidal alkaloids cortistatins A and J. The key features of our strategy include (i) an efficient Knoevenagel/electrocyclic strategy to couple the diketone and the CD-ring fragment, (ii) a chemoselective radical cyclization to construct the oxabicyclo[3.2.1]octene B-ring system, (iii) a highly stereocontrolled installation of the isoquinoline unit, and (iv) a late-stage functionalization of the A-ring.

FORMATION OF SUBSTITUTED BENZOCYCLOBUTENES THROUGH FLASH VACUUM PYROLYSIS

Benzocyclobutenes carrying a substituent in the four membered ring are obtained in high yield from 2-methyl benzaldehydes through a reaction sequence involving a pyrolitic 1,4-elimination of HCl in the crucial step.