4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

Base Information

Chemical Name:4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester
CAS No.:1262396-25-7
Molecular Formula:C₁₈H₂₃NO₅
Molecular Weight:333.384
Hs Code.:

Synonyms:4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

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Chemical Property of 4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

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Technology Process of 4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

There total 2 articles about 4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: (S)-4-oxo-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester tert-butyl amine salt

: 100-51-6,185532-71-2
benzyl alcohol

: 1262396-25-7
4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

Guidance literature:: (S)-4-oxo-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester tert-butyl amine salt; With hydrogenchloride; sodium chloride; In water; ethyl acetate; at 0 ℃;

benzyl alcohol; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 2(S)-[(2-methoxycarbonylethyl)amino]succinic acid 4-methyl ester

: 1262396-25-7
4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate; methanol / tetrahydrofuran / 0.5 h / 0 - 85 °C / Inert atmosphere

1.2: 20 h / 110 °C

1.3: 0 °C / pH 2.5

2.1: hydrogenchloride; sodium chloride / ethyl acetate; water / 0 °C

2.2: 0 - 20 °C

With hydrogenchloride; methanol; sodium methylate; sodium chloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield: 57.4%

: 1262396-25-7
4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

: 1779-49-3
Methyltriphenylphosphonium bromide

: 1262396-27-9
4-methylene-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester

Guidance literature:: Methyltriphenylphosphonium bromide; With sodium hexamethyldisilazane; In toluene; at 0 - 20 ℃;

4-oxo-1-(tert-butoxycarbonyl)piperidine-2(S)-carboxylic acid benzyl ester; In toluene; at 0 - 20 ℃;