(R,S)-3-(2-((4-fluorophenyl)(hydroxy)methyl)quinazolin-4-ylamino)-1H-pyrazole-5-carbonitrile

Base Information

Chemical Name:(R,S)-3-(2-((4-fluorophenyl)(hydroxy)methyl)quinazolin-4-ylamino)-1H-pyrazole-5-carbonitrile
CAS No.:1241914-97-5
Molecular Formula:C₁₉H₁₃FN₆O
Molecular Weight:360.35
Hs Code.:

Synonyms:(R,S)-3-(2-((4-fluorophenyl)(hydroxy)methyl)quinazolin-4-ylamino)-1H-pyrazole-5-carbonitrile

Suppliers and Price of (R,S)-3-(2-((4-fluorophenyl)(hydroxy)methyl)quinazolin-4-ylamino)-1H-pyrazole-5-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (R,S)-3-(2-((4-fluorophenyl)(hydroxy)methyl)quinazolin-4-ylamino)-1H-pyrazole-5-carbonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R,S)-3-(2-((4-fluorophenyl)(hydroxy)methyl)quinazolin-4-ylamino)-1H-pyrazole-5-carbonitrile

There total 7 articles about (R,S)-3-(2-((4-fluorophenyl)(hydroxy)methyl)quinazolin-4-ylamino)-1H-pyrazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1241914-85-1
3-(2-(4-fluorobenzoyl)quinazolin-4-ylamino)-1H-pyrazole-5-carbonitrile

: 1241914-97-5
(R,S)-3-(2-((4-fluorophenyl)(hydroxy)methyl)quinazolin-4-ylamino)-1H-pyrazole-5-carbonitrile

Guidance literature:: With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 34632-69-4
ethyl 4-chloro-quinazoline-2-carboxylate

: 1241914-97-5
(R,S)-3-(2-((4-fluorophenyl)(hydroxy)methyl)quinazolin-4-ylamino)-1H-pyrazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / tetrahydrofuran

3: N,N-dimethyl-formamide; methanol

4: sodium borohydrid / tetrahydrofuran; methanol

With hydrogenchloride; sodium borohydrid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1241914-97-5
(R,S)-3-(2-((4-fluorophenyl)(hydroxy)methyl)quinazolin-4-ylamino)-1H-pyrazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / tetrahydrofuran

2: DIEA / N,N-dimethyl-formamide; water

3: N,N-dimethyl-formamide; methanol

4: sodium borohydrid / tetrahydrofuran; methanol

With hydrogenchloride; DIEA; sodium borohydrid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;