N-(3-benzoyl-4-trifluoroacetylaminophenyl)-3-[5-(4-cyanophenyl)-2-furyl]acrylic acid amide

Base Information

Chemical Name:N-(3-benzoyl-4-trifluoroacetylaminophenyl)-3-[5-(4-cyanophenyl)-2-furyl]acrylic acid amide
CAS No.:765938-39-4
Molecular Formula:C₂₉H₁₈F₃N₃O₄
Molecular Weight:529.475
Hs Code.:

Synonyms:N-(3-benzoyl-4-trifluoroacetylaminophenyl)-3-[5-(4-cyanophenyl)-2-furyl]acrylic acid amide

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Chemical Property of N-(3-benzoyl-4-trifluoroacetylaminophenyl)-3-[5-(4-cyanophenyl)-2-furyl]acrylic acid amide

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Technology Process of N-(3-benzoyl-4-trifluoroacetylaminophenyl)-3-[5-(4-cyanophenyl)-2-furyl]acrylic acid amide

There total 5 articles about N-(3-benzoyl-4-trifluoroacetylaminophenyl)-3-[5-(4-cyanophenyl)-2-furyl]acrylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 357436-78-3
N-(4-amino-2-benzoylphenyl)-trifluoroacetic acid amide

: (E)-3-[5-(4-Cyano-phenyl)-furan-2-yl]-acryloyl chloride

: 765938-39-4
N-(3-benzoyl-4-trifluoroacetylaminophenyl)-3-[5-(4-cyanophenyl)-2-furyl]acrylic acid amide

Guidance literature:: In toluene; for 2h; Heating;
DOI:10.1016/j.bmc.2004.07.010

Reference yield:

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 765938-39-4
N-(3-benzoyl-4-trifluoroacetylaminophenyl)-3-[5-(4-cyanophenyl)-2-furyl]acrylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / potassium carbonate / tetrakis(triphenylphosphine)palladium⁽⁰⁾; [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) chloride / toluene; H₂O; ethanol / 5 h / Heating

2: 64 percent / pyridine; piperidine / 2 h / Heating

3: thionyl chloride / toluene / 2 h / Heating

4: 72 percent / toluene / 2 h / Heating

With piperidine; pyridine; thionyl chloride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; 1: Suzuki coupling / 2: Knoevenagel condensation;
DOI:10.1016/j.bmc.2004.07.010

Reference yield:

: 126747-14-6
4-cyanophenylboronic acid

: 765938-39-4
N-(3-benzoyl-4-trifluoroacetylaminophenyl)-3-[5-(4-cyanophenyl)-2-furyl]acrylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / potassium carbonate / tetrakis(triphenylphosphine)palladium⁽⁰⁾; [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) chloride / toluene; H₂O; ethanol / 5 h / Heating

2: 64 percent / pyridine; piperidine / 2 h / Heating

3: thionyl chloride / toluene / 2 h / Heating

4: 72 percent / toluene / 2 h / Heating

With piperidine; pyridine; thionyl chloride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; 1: Suzuki coupling / 2: Knoevenagel condensation;
DOI:10.1016/j.bmc.2004.07.010