2-(2-hydroxy-1,1-dimethylethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 2-(2-hydroxy-1,1-dimethylethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester
• CAS No.: 925691-21-0
• Molecular Formula: C₁₈H₂₆N₂O₄
• Molecular Weight: 334.415

Synonyms:2-(2-hydroxy-1,1-dimethylethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester

Chemical Property of 2-(2-hydroxy-1,1-dimethylethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester

Chemical Property:

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Technology Process of 2-(2-hydroxy-1,1-dimethylethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester

There total 3 articles about 2-(2-hydroxy-1,1-dimethylethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-benzyloxycarbonyl D/L-pipecolinic acid (28697-07-6) + 2-Amino-2-methyl-1-propanol (124-68-5) → 2-(2-hydroxy-1,1-dimethylethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester (925691-21-0)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1246/cl.2006.1424

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 2-(2-hydroxy-1,1-dimethylethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester (925691-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / NaHCO₃ / H₂O / 3 h / 20 °C

2: 79 percent / EDC; HOBt / CH₂Cl₂ / 20 °C

With sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; water;

DOI:10.1246/cl.2006.1424

Reference yield:

pipecolic Acid (4043-87-2,83680-83-5) → 2-(2-hydroxy-1,1-dimethylethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester (925691-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / NaHCO₃ / H₂O / 3 h / 20 °C

2: 79 percent / EDC; HOBt / CH₂Cl₂ / 20 °C

With sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; water;

DOI:10.1246/cl.2006.1424

upstream raw materials:

N-benzyloxycarbonyl D/L-pipecolinic acid

2-Amino-2-methyl-1-propanol

benzyl chloroformate

pipecolic Acid

Downstream raw materials:

2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-piperidine-1-carboxylic acid benzyl ester

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