{[6-Bromo-2-(4-fluoro-phenyl)-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester

Base Information

Chemical Name:{[6-Bromo-2-(4-fluoro-phenyl)-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester
CAS No.:148887-76-7
Molecular Formula:C₂₁H₁₈BrFN₂O₃
Molecular Weight:445.288
Hs Code.:

Synonyms:{[6-Bromo-2-(4-fluoro-phenyl)-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester

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Chemical Property of {[6-Bromo-2-(4-fluoro-phenyl)-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester

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Technology Process of {[6-Bromo-2-(4-fluoro-phenyl)-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester

There total 3 articles about {[6-Bromo-2-(4-fluoro-phenyl)-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 13200-60-7
Sarcosine ethyl ester

: 391-23-1
6-bromo-2-(4-fluoro-phenyl)-quinoline-4-carboxylic acid

: 148887-76-7
{[6-Bromo-2-(4-fluoro-phenyl)-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile; for 4h; Ambient temperature;
DOI:10.1016/0223-5234(92)90032-V

Reference yield:

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 148887-76-7
{[6-Bromo-2-(4-fluoro-phenyl)-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / 34percent KOH / ethanol / 14 h / 50 - 60 °C

2: 51 percent / N,N'-dicyclohexyl carbodiimide / tetrahydrofuran; acetonitrile / 4 h / Ambient temperature

With potassium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/0223-5234(92)90032-V

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 148887-76-7
{[6-Bromo-2-(4-fluoro-phenyl)-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / 34percent KOH / ethanol / 14 h / 50 - 60 °C

2: 51 percent / N,N'-dicyclohexyl carbodiimide / tetrahydrofuran; acetonitrile / 4 h / Ambient temperature

With potassium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/0223-5234(92)90032-V