6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid

Base Information

Chemical Name:6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid
CAS No.:391-23-1
Molecular Formula:C16H9BrFNO2
Molecular Weight:346.15
Hs Code.:2933499090
DSSTox Substance ID:DTXSID50358321
Wikidata:Q82138806
Mol file:391-23-1.mol

Synonyms:6-bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid;391-23-1;6-Bromo-2-(4-fluoro-phenyl)-quinoline-4-carboxylic acid;Oprea1_632915;6-bromo-2-(4-fluorophenyl)-4-quinolinecarboxylic acid;DTXSID50358321;BBL013773;MFCD02056374;STK409486;AKOS000265580;SB72528;LS-02345;CS-0316025;EU-0075191;FT-0734509;SR-01000463949;SR-01000463949-1

Suppliers and Price of 6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylicAcid
1g
$ 310.00

TRC
6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylicAcid
100mg
$ 45.00

TRC
6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylicAcid
500mg
$ 200.00

Matrix Scientific
6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid
500mg
$ 95.00

Crysdot
6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylicacid 95+%
5g
$ 349.00

Chemenu
6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylicacid 95%
5g
$ 329.00

Biosynth Carbosynth
6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid
1 g
$ 128.00

Biosynth Carbosynth
6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid
500 mg
$ 75.00

Biosynth Carbosynth
6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid
2 g
$ 218.00

Biosynth Carbosynth
6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid
10 g
$ 741.00

Total 11 raw suppliers

Chemical Property of 6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid

Chemical Property:

PSA：50.19000
LogP:4.50160
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:344.98007
Heavy Atom Count:21
Complexity:387

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC3=C(C=C(C=C3)Br)C(=C2)C(=O)O)F

Technology Process of 6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid

There total 3 articles about 6-Bromo-2-(4-fluorophenyl)quinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 403-42-9
1-(4-fluorophenyl)ethanone

: 391-23-1
6-bromo-2-(4-fluoro-phenyl)-quinoline-4-carboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 50 - 60 ℃; for 14h;
DOI:10.1016/0223-5234(92)90032-V

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 127-17-3
2-oxo-propionic acid

: 106-40-1
4-bromo-aniline

: 391-23-1
6-bromo-2-(4-fluoro-phenyl)-quinoline-4-carboxylic acid

Guidance literature:: 4-fluorobenzaldehyde; 2-oxo-propionic acid; In ethanol; for 0.166667h; Reflux;

4-bromo-aniline; With trifluoroacetic acid; In ethanol; for 3h; Reflux;
DOI:10.1002/jhet.3617

Reference yield:

: 462-06-6
fluorobenzene

: 391-23-1
6-bromo-2-(4-fluoro-phenyl)-quinoline-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: carbon disulfide; AlCl₃

2: aq.-ethanolic KOH

With carbon disulfide; potassium hydroxide; aluminium trichloride;