methyl 3-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate

Base Information

Chemical Name:methyl 3-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate
CAS No.:1361570-31-1
Molecular Formula:C₁₅H₁₀F₃NO₃
Molecular Weight:309.245
Hs Code.:

Synonyms:methyl 3-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate

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Chemical Property of methyl 3-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate

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Technology Process of methyl 3-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate

There total 2 articles about methyl 3-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1048340-35-7
3,5-difluoropyridine-2-carbonyl chloride

: 57486-67-6
methyl o-fluorophenylacetate

: 1361570-31-1
methyl 3-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate

Guidance literature:: methyl o-fluorophenylacetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

3,5-difluoropyridine-2-carbonyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 745784-04-7
3,5-difluoropyridine-2-carboxylic acid

: 1361570-31-1
methyl 3-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 5 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 20 °C / Inert atmosphere

With thionyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran;