N,N'-bis[4-(dimethylamino)phenyl]urea

Base Information

• Chemical Name: N,N'-bis[4-(dimethylamino)phenyl]urea
• CAS No.: 5260-04-8
• Molecular Formula: C₁₇H₂₂N₄O
• Molecular Weight: 298.388
• Mol file: 5260-04-8.mol

Synonyms:N,N'-bis[4-(dimethylamino)phenyl]urea

Chemical Property of N,N'-bis[4-(dimethylamino)phenyl]urea

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N,N'-bis[4-(dimethylamino)phenyl]urea

There total 30 articles about N,N'-bis[4-(dimethylamino)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

carbon dioxide (124-38-9,18923-20-1) + N,N-dimethyl-N'-trimethylsilanyl-benzene-1,4-diamine → N,N'-bis[4-(dimethylamino)phenyl]urea (5260-04-8)

Guidance literature:

With pyridine; C₁₄H₃₄Cl₂InNO₂Si₂; In toluene; at 110 ℃; for 12h; under 2280.15 Torr;

DOI:10.1002/anie.201708921

Reference yield: 85.0%

4-amino-N,N-dimethylaniline (99-98-9) + urea (57-13-6) → N,N'-bis[4-(dimethylamino)phenyl]urea (5260-04-8)

Guidance literature:

With sodium hydrogen sulfite; tetrabutylammonium acetate; In water; for 48h; Inert atmosphere; Reflux;

DOI:10.1021/jo9011392

Reference yield: 85.0%

4-amino-N,N-dimethylaniline (99-98-9) + 1,1'-carbonyldiimidazole (530-62-1) → N,N'-bis[4-(dimethylamino)phenyl]urea (5260-04-8)

Guidance literature:

In tetrahydrofuran; for 24h; Reflux;

DOI:10.1039/c8ra03042a

upstream raw materials:

pyridine

1,5-pentanedioic acid

bis-(4-dimethylamino-phenyl)-carbodiimide

benzene

Downstream raw materials:

hexa-N-methyl-4,4'-ureylene-di-anilinium; bis-dimethyl sulfate

Refernces

• 1、 -. "Urea-based derivative and synthesis method thereof". Paragraph 0056-0062. . Retrieved 2020/02/08.
• 2、 Kwiatkowski, Adam,J?drzejewska, Beata,Józefowicz, Marek,Grela, Izabela,O?mia?owski, Borys. "The: Trans / cis photoisomerization in hydrogen bonded complexes with stability controlled by substituent effects: 3-(6-aminopyridin-3-yl)acrylate case study". . p. 23698 - 23710. Retrieved 2018/07/13.