6-methyl-N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}-1,3-thiazol-2-yl)pyridin-2-amine

Base Information

Chemical Name:6-methyl-N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}-1,3-thiazol-2-yl)pyridin-2-amine
CAS No.:1426259-53-1
Molecular Formula:C₂₅H₂₆N₆S
Molecular Weight:442.588
Hs Code.:

Synonyms:6-methyl-N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}-1,3-thiazol-2-yl)pyridin-2-amine

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Chemical Property of 6-methyl-N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}-1,3-thiazol-2-yl)pyridin-2-amine

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Technology Process of 6-methyl-N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}-1,3-thiazol-2-yl)pyridin-2-amine

There total 7 articles about 6-methyl-N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}-1,3-thiazol-2-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1426260-18-5
N-(6-methylpyridin-2-yl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-amin

: 364794-58-1
1-N-(5-bromopyridin-2-yl)-4-methylpiperazine

: 1426259-53-1
6-methyl-N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}-1,3-thiazol-2-yl)pyridin-2-amine

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201300007

Reference yield:

: 1310049-89-8
[4-(4-bromophenyl)-1,3-thiazol-2-yl]-(6-methylpyridin-2-yl)amine

: 1426259-53-1
6-methyl-N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}-1,3-thiazol-2-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate / water; 1,4-dioxane / 80 °C / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; potassium carbonate; In 1,4-dioxane; water; 1: |Suzuki-Miyaura Coupling;
DOI:10.1002/cmdc.201300007

Reference yield:

: 1824-81-3
2-Amino-6-methylpyridine

: 1426259-53-1
6-methyl-N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}-1,3-thiazol-2-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: acetone / Reflux

2: sodium hydroxide / methanol / 0.5 h / Reflux

3: ethanol / 3 h / Reflux

4: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

5: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate / water; 1,4-dioxane / 80 °C / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; potassium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; water; acetone; 3: |Hantzsch Thiazole Synthesis / 4: |Suzuki-Miyaura Coupling;
DOI:10.1002/cmdc.201300007