2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester

Base Information

• Chemical Name: 2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester
• CAS No.: 934500-67-1
• Molecular Formula: C₄₅H₅₈N₈O₇Si₂
• Molecular Weight: 879.176
• Mol file: 934500-67-1.mol

Synonyms:2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester

Chemical Property of 2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester

There total 3 articles about 2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-[(2-azidomethyl)-benzoyloxy]benzyl alcohol + 2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester (934500-66-0) → 2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester (934500-67-1)

Guidance literature:

2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester; With 1-Methylpyrrolidine; In dichloromethane; at 0 ℃; for 0.166667h;

4-[(2-azidomethyl)-benzoyloxy]benzyl alcohol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2007.01.064

Reference yield:

(4-hydroxyphenyl)methanol (623-05-2) → 2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester (934500-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 71 percent / triethylamine / ethyl acetate / 5 h / 0 °C

2.1: N-methylpyrrolidine / CH₂Cl₂ / 0.17 h / 0 °C

2.2: 77 percent / DBU / CH₂Cl₂ / 1.5 h / 0 °C

With 1-Methylpyrrolidine; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1016/j.tetlet.2007.01.064

Reference yield:

2-(azidomethyl)benzoyl chloride (289712-58-9) → 2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester (934500-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 71 percent / triethylamine / ethyl acetate / 5 h / 0 °C

2.1: N-methylpyrrolidine / CH₂Cl₂ / 0.17 h / 0 °C

2.2: 77 percent / DBU / CH₂Cl₂ / 1.5 h / 0 °C

With 1-Methylpyrrolidine; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1016/j.tetlet.2007.01.064

upstream raw materials:

2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester

(4-hydroxyphenyl)methanol

2-(azidomethyl)benzoyl chloride

Downstream raw materials:

2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester

N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide