2S-2-hydroxy-2-((1-methoxymethyl)cyclohexyl)-N-methyl acetamide

Base Information

• Chemical Name: 2S-2-hydroxy-2-((1-methoxymethyl)cyclohexyl)-N-methyl acetamide
• CAS No.: 402913-46-6
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.293
• Mol file: 402913-46-6.mol

Synonyms:2S-2-hydroxy-2-((1-methoxymethyl)cyclohexyl)-N-methyl acetamide

Chemical Property of 2S-2-hydroxy-2-((1-methoxymethyl)cyclohexyl)-N-methyl acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2S-2-hydroxy-2-((1-methoxymethyl)cyclohexyl)-N-methyl acetamide

There total 5 articles about 2S-2-hydroxy-2-((1-methoxymethyl)cyclohexyl)-N-methyl acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2S,5S,6R-2-((1-methoxymethyl)cyclohexyl)-4,5-dimethyl-6-phenyl-morpholin-3-one (402913-45-5) → 2S-2-hydroxy-2-((1-methoxymethyl)cyclohexyl)-N-methyl acetamide (402913-46-6)

Guidance literature:

With ammonia; sodium; In tetrahydrofuran; at -78 ℃; for 0.0583333h;

DOI:10.1016/S0040-4020(03)00408-3

Reference yield:

cyclohexylmagnesium bromide (931-50-0) → 2S-2-hydroxy-2-((1-methoxymethyl)cyclohexyl)-N-methyl acetamide (402913-46-6)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran / 1 h / 20 °C

2: 89 percent / BF₃*Et₂O / CH₂Cl₂ / 6 h / 20 °C

3: 93 percent / H₂SO₄; glacial acetic acid / 0.03 h / Heating

4: 93 percent / titanium tetrachloride; triethylsilane / CH₂Cl₂ / 24 h / 20 °C

5: 50 percent / sodium; liq. ammonia / tetrahydrofuran / 0.06 h / -78 °C

With triethylsilane; sulfuric acid; boron trifluoride diethyl etherate; ammonia; sodium; titanium tetrachloride; acetic acid; In tetrahydrofuran; dichloromethane; 3: Prins reaction;

DOI:10.1016/S0040-4020(03)00408-3

Reference yield:

(5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenyl-morpholin-3-one (402913-43-3) → 2S-2-hydroxy-2-((1-methoxymethyl)cyclohexyl)-N-methyl acetamide (402913-46-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / H₂SO₄; glacial acetic acid / 0.03 h / Heating

2: 93 percent / titanium tetrachloride; triethylsilane / CH₂Cl₂ / 24 h / 20 °C

3: 50 percent / sodium; liq. ammonia / tetrahydrofuran / 0.06 h / -78 °C

With triethylsilane; sulfuric acid; ammonia; sodium; titanium tetrachloride; acetic acid; In tetrahydrofuran; dichloromethane; 1: Prins reaction;

DOI:10.1016/S0040-4020(03)00408-3

upstream raw materials:

2S,5S,6R-2-((1-methoxymethyl)cyclohexyl)-4,5-dimethyl-6-phenyl-morpholin-3-one

cyclohexylmagnesium bromide

(5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenyl-morpholin-3-one

(5S,6R)-2-cyclohexyl-2-hydroxy-4,5-dimethyl-6-phenyl-morpholin-3-one