(5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenylmorpholin-3-one

Base Information

Chemical Name:(5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenylmorpholin-3-one
CAS No.:402913-43-3
Molecular Formula:C18H23NO2
Molecular Weight:285.386
Hs Code.:
DSSTox Substance ID:DTXSID40514570
Nikkaji Number:J1.649.804A
Wikidata:Q82374964
Mol file:402913-43-3.mol

Synonyms:402913-43-3;(5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenylmorpholin-3-one;DTXSID40514570

Suppliers and Price of (5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenylmorpholin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenylmorpholin-3-one

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:285.172878976
Heavy Atom Count:21
Complexity:415

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(OC(=C2CCCCC2)C(=O)N1C)C3=CC=CC=C3
Isomeric SMILES:C[C@H]1[C@H](OC(=C2CCCCC2)C(=O)N1C)C3=CC=CC=C3

Technology Process of (5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenylmorpholin-3-one

There total 4 articles about (5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenylmorpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 402913-42-2
(5S,6R)-2-cyclohexyl-2-hydroxy-4,5-dimethyl-6-phenyl-morpholin-3-one

: 402913-43-3
(5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenyl-morpholin-3-one

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1016/S0040-4020(03)00408-3

Reference yield:

: 931-50-0
cyclohexylmagnesium bromide

: 402913-43-3
(5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 20 °C

2: 89 percent / BF₃*Et₂O / CH₂Cl₂ / 6 h / 20 °C

With boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(03)00408-3

Reference yield:

: 78927-93-2
(5S,6R)-4,5-dimethyl-6-phenyl-morpholin-2,3-dione

: 402913-43-3
(5S,6R)-2-cyclohexylidene-4,5-dimethyl-6-phenyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 20 °C

2: 89 percent / BF₃*Et₂O / CH₂Cl₂ / 6 h / 20 °C

With boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(03)00408-3