3,3-dimethyl-6-(toluene-4-sulfonyl)-6-aza-3-sila-bicyclo[3.1.0]hexane

Base Information

• Chemical Name: 3,3-dimethyl-6-(toluene-4-sulfonyl)-6-aza-3-sila-bicyclo[3.1.0]hexane
• CAS No.: 472966-01-1
• Molecular Formula: C₁₃H₁₉NO₂SSi
• Molecular Weight: 281.451
• Mol file: 472966-01-1.mol

Synonyms:3,3-dimethyl-6-(toluene-4-sulfonyl)-6-aza-3-sila-bicyclo[3.1.0]hexane

Chemical Property of 3,3-dimethyl-6-(toluene-4-sulfonyl)-6-aza-3-sila-bicyclo[3.1.0]hexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-dimethyl-6-(toluene-4-sulfonyl)-6-aza-3-sila-bicyclo[3.1.0]hexane

There total 1 articles about 3,3-dimethyl-6-(toluene-4-sulfonyl)-6-aza-3-sila-bicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1,1-Dimethylsilacyclopent-3-en (16054-12-9) + chloroamine-T (127-65-1) → 3,3-dimethyl-6-(toluene-4-sulfonyl)-6-aza-3-sila-bicyclo[3.1.0]hexane (472966-01-1)

Guidance literature:

With PTAB; In acetonitrile; at 20 ℃; for 5h;

DOI:10.1016/S0040-4039(02)01085-7

Reference yield: 75.0%

3,3-dimethyl-6-(toluene-4-sulfonyl)-6-aza-3-sila-bicyclo[3.1.0]hexane (472966-01-1) → N-((3S,4R)-4-Cyano-1,1-dimethyl-silolan-3-yl)-4-methyl-benzenesulfonamide

Guidance literature:

In toluene; at 100 ℃; for 17h;

DOI:10.1016/S0040-4039(02)01085-7

Reference yield:

3,3-dimethyl-6-(toluene-4-sulfonyl)-6-aza-3-sila-bicyclo[3.1.0]hexane (472966-01-1) → C19H28N2O4SSi

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / toluene / 17 h / 100 °C

2: 95 percent / DMAP / acetonitrile / 5 h / 20 °C

With dmap; In toluene; acetonitrile;

DOI:10.1016/S0040-4039(02)01085-7

upstream raw materials:

1,1-Dimethylsilacyclopent-3-en

chloroamine-T