dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzylamino)-pyrimidine

Base Information

• Chemical Name: dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzylamino)-pyrimidine
• CAS No.: 115617-88-4
• Molecular Formula: C₁₅H₁₈ClN₃O
• Molecular Weight: 291.78
• Mol file: 115617-88-4.mol

Synonyms:dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzylamino)-pyrimidine

Chemical Property of dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzylamino)-pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzylamino)-pyrimidine

There total 4 articles about dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzylamino)-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

α-[RS]Ethyl-4-hydroxybenzylamine (85068-38-8) + 4,5-Dichloro-6-ethylpyrimidine (115617-41-9) → dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzylamino)-pyrimidine (115617-88-4)

Guidance literature:

With triethylamine; dmap; In ethanol; for 8h; Heating;

DOI:10.1002/(SICI)1096-9063(1998110)54:3<223::AID-PS814>3.0.CO;2-R

Reference yield:

α-[RS]Ethyl-4-hydroxybenzylamine (85068-38-8) → dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzylamino)-pyrimidine (115617-88-4)

Guidance literature:

With sodium hydroxide; triethylamine; In ethanol; toluene;

Reference yield:

1-(4'-hydroxy)propiophenone oxime (133595-72-9) → dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzylamino)-pyrimidine (115617-88-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / H₂ / Pd/C / aq. HCl; ethanol / 5 h / 50 °C / 22065.2 Torr

2: 52 percent / Et₃N / 4-(N,N-dimethylamino)pyridine / ethanol / 8 h / Heating

With hydrogen; triethylamine; dmap; palladium on activated charcoal; In hydrogenchloride; ethanol; 1: Hydrogenation / 2: Substitution;

DOI:10.1002/(SICI)1096-9063(1998110)54:3<223::AID-PS814>3.0.CO;2-R

upstream raw materials:

α-[RS]Ethyl-4-hydroxybenzylamine

4,5-Dichloro-6-ethylpyrimidine

1-(4'-hydroxy)propiophenone oxime

4-hydroxypropiophenone

Downstream raw materials:

dl-5-chloro-6-ethyl-4-(α-ethyl-4-bromodifluoromethoxybenzylamino)pyrimidine