N-(5-(hex-1-yn-1-yl)-2-phenyloxazol-4-yl)-4-methyl-N-phenylbenzenesulfonamide

Base Information

• Chemical Name: N-(5-(hex-1-yn-1-yl)-2-phenyloxazol-4-yl)-4-methyl-N-phenylbenzenesulfonamide
• CAS No.: 1337936-58-9
• Molecular Formula: C₂₈H₂₆N₂O₃S
• Molecular Weight: 470.592
• Mol file: 1337936-58-9.mol

Synonyms:N-(5-(hex-1-yn-1-yl)-2-phenyloxazol-4-yl)-4-methyl-N-phenylbenzenesulfonamide

Chemical Property of N-(5-(hex-1-yn-1-yl)-2-phenyloxazol-4-yl)-4-methyl-N-phenylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-(hex-1-yn-1-yl)-2-phenyloxazol-4-yl)-4-methyl-N-phenylbenzenesulfonamide

There total 5 articles about N-(5-(hex-1-yn-1-yl)-2-phenyloxazol-4-yl)-4-methyl-N-phenylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

benzoyl(pyridin-1-ium-1-yl)amide (23031-08-5) + 4-methyl-N-octa-1,3-diynyl-N-phenylbenzenesulfonamide (1337936-30-7) → N-(5-(hex-1-yn-1-yl)-2-phenyloxazol-4-yl)-4-methyl-N-phenylbenzenesulfonamide (1337936-58-9)

Guidance literature:

With dichloro(2-picolinato)gold(III); In toluene; at 90 ℃; for 18h; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201103563

Reference yield:

phenyl toluenesulfonamide (68-34-8) → N-(5-(hex-1-yn-1-yl)-2-phenyloxazol-4-yl)-4-methyl-N-phenylbenzenesulfonamide (1337936-58-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine; oxygen; sodium carbonate; copper dichloride / toluene / 0.25 h / 70 °C

1.2: 8 h / 70 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine / toluene / 20 °C / Inert atmosphere

4.1: dichloro(2-picolinato)gold(III) / toluene / 18 h / 90 °C / Inert atmosphere

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(2-picolinato)gold(III); tetrabutyl ammonium fluoride; oxygen; sodium carbonate; diisopropylamine; copper dichloride; In tetrahydrofuran; toluene;

DOI:10.1002/anie.201103563

Reference yield:

benzoyl chloride (98-88-4) → N-(5-(hex-1-yn-1-yl)-2-phenyloxazol-4-yl)-4-methyl-N-phenylbenzenesulfonamide (1337936-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 0 °C

2: dichloro(2-picolinato)gold(III) / toluene / 18 h / 90 °C / Inert atmosphere

With dichloro(2-picolinato)gold(III); sodium hydroxide; In water; toluene;

DOI:10.1002/anie.201103563

upstream raw materials:

benzoyl(pyridin-1-ium-1-yl)amide

4-methyl-N-octa-1,3-diynyl-N-phenylbenzenesulfonamide

phenyl toluenesulfonamide

benzoyl chloride