C₈H₁₂N₂O₂S

Base Information

• Chemical Name: C₈H₁₂N₂O₂S
• CAS No.: 1108737-66-1
• Molecular Formula: C₈H₁₂N₂O₂S
• Molecular Weight: 200.261
• Mol file: 1108737-66-1.mol

Synonyms:C₈H₁₂N₂O₂S

Chemical Property of C₈H₁₂N₂O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₈H₁₂N₂O₂S

There total 1 articles about C₈H₁₂N₂O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

ethyl 2-(methylthio)pyrimidine-5-carboxylate (73781-88-1) → [2-(methylsulfanyl)-5-pyrimidinyl]methanol (19858-50-5) + ethyl 1,6-dihydro-2-(methylthio)pyrimidine-5-carboxylate (1108737-66-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 10 ℃; for 16h;

DOI:10.3184/030823407X240872

Reference yield: 28.0%

C8H12N2O2S (1108737-66-1) + aniline (62-53-3) → C13H15N3O2

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In 1,2-dichloro-ethane; for 15h; Reflux;

DOI:10.1016/j.tetlet.2020.152760

Reference yield:

C8H12N2O2S (1108737-66-1) → (E)-ethyl 3-((tert-butoxycarbonyl)amino)-2-[((Z)-2-methyl-3-phenylisothioureido)methyl]acrylate (1352328-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / Inert atmosphere

2: pyridinium p-toluenesulfonate / dichloromethane / 9 h / 20 °C / Inert atmosphere

With pyridinium p-toluenesulfonate; sodium hydride; In dichloromethane;

DOI:10.1016/j.tetlet.2011.10.130

upstream raw materials:

ethyl 2-(methylthio)pyrimidine-5-carboxylate

Downstream raw materials:

(E)-ethyl 3-((tert-butoxycarbonyl)amino)-2-[((Z)-2-methyl-3-phenylisothioureido)methyl]acrylate

ethyl 3-((tert-butoxycarbonyl)amino)-2-[(3-(4-methoxyphenyl)-2-methylisothioureido)methyl]acrylate

ethyl 3-((tert-butoxycarbonyl)amino)-2-((2-methyl-3-(p-tolyl)isothioureido)methyl)acrylate

ethyl 3-((tert-butoxycarbonyl)amino)-2-((2-methyl-3-(o-tolyl)isothioureido)methyl)acrylate

Refernces