17β-[N-(3'-trifluoromethyl-4'-nitrophenyl)aminocarbonyl]-5-oxo-A-nor-3,5-secoandrostan-3-oic acid

Base Information

Chemical Name:17β-[N-(3'-trifluoromethyl-4'-nitrophenyl)aminocarbonyl]-5-oxo-A-nor-3,5-secoandrostan-3-oic acid
CAS No.:206351-42-0
Molecular Formula:C₂₆H₃₁F₃N₂O₆
Molecular Weight:524.537
Hs Code.:

Synonyms:17β-[N-(3'-trifluoromethyl-4'-nitrophenyl)aminocarbonyl]-5-oxo-A-nor-3,5-secoandrostan-3-oic acid

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Chemical Property of 17β-[N-(3'-trifluoromethyl-4'-nitrophenyl)aminocarbonyl]-5-oxo-A-nor-3,5-secoandrostan-3-oic acid

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Technology Process of 17β-[N-(3'-trifluoromethyl-4'-nitrophenyl)aminocarbonyl]-5-oxo-A-nor-3,5-secoandrostan-3-oic acid

There total 7 articles about 17β-[N-(3'-trifluoromethyl-4'-nitrophenyl)aminocarbonyl]-5-oxo-A-nor-3,5-secoandrostan-3-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.55%

: 206351-41-9
N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxoandrost-4-ene-17β-carboxamide

: 206351-42-0
17β-[N-(3'-trifluoromethyl-4'-nitrophenyl)aminocarbonyl]-5-oxo-A-nor-3,5-secoandrostan-3-oic acid

Guidance literature:: With potassium permanganate; sodium periodate; sodium carbonate; In water; tert-butyl alcohol; for 0.5h; Heating;
DOI:10.3987/COM-97-S(N)35

Reference yield:

: 302-97-6
androst-4-en-3-one-17β-carboxylic acid

: 206351-42-0
17β-[N-(3'-trifluoromethyl-4'-nitrophenyl)aminocarbonyl]-5-oxo-A-nor-3,5-secoandrostan-3-oic acid

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂; pyridine / toluene / 3 h / 5 °C

2: 0.57 g / toluene / 20 °C

3: aq. Na₂CO₃; NaIO₄; KMnO₄ / 2-methyl-propan-2-ol / 3 h / Heating

With pyridine; potassium permanganate; sodium periodate; thionyl chloride; sodium carbonate; In toluene; tert-butyl alcohol; 1: Substitution / 2: Substitution / 3: Ring cleavage;
DOI:10.1016/S0968-0896(99)00169-8

Reference yield:

: 57072-90-9
3-oxoandrost-4-ene-17β-carboxylic acid chloride

: 206351-42-0
17β-[N-(3'-trifluoromethyl-4'-nitrophenyl)aminocarbonyl]-5-oxo-A-nor-3,5-secoandrostan-3-oic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 0.57 g / toluene / 20 °C

2: aq. Na₂CO₃; NaIO₄; KMnO₄ / 2-methyl-propan-2-ol / 3 h / Heating

With potassium permanganate; sodium periodate; sodium carbonate; In toluene; tert-butyl alcohol; 1: Substitution / 2: Ring cleavage;
DOI:10.1016/S0968-0896(99)00169-8