2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, 1-[1-(phenylmethyl)-4-piperidinyl]5-(1-methylethyl) ester

Base Information

• Chemical Name: 2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, 1-[1-(phenylmethyl)-4-piperidinyl]5-(1-methylethyl) ester
• CAS No.: 108931-62-0
• Molecular Formula: C₂₉H₃₄N₄O₇
• Molecular Weight: 550.612

Synonyms:2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, 1-[1-(phenylmethyl)-4-piperidinyl]5-(1-methylethyl) ester

Chemical Property of 2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, 1-[1-(phenylmethyl)-4-piperidinyl]5-(1-methylethyl) ester

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Technology Process of 2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, 1-[1-(phenylmethyl)-4-piperidinyl]5-(1-methylethyl) ester

There total 2 articles about 2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, 1-[1-(phenylmethyl)-4-piperidinyl]5-(1-methylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosgene (75-44-5) + 1-benzyl-4-hydroxypiperidine (4727-72-4) + 1,4-Dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid,1-methylethyl ester (108931-52-8) → 2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, 1-[1-(phenylmethyl)-4-piperidinyl]5-(1-methylethyl) ester (108931-62-0)

Guidance literature:

With triethylamine; In dichloromethane; benzene;

Reference yield:

phosgene (75-44-5) + 1-benzyl-4-hydroxypiperidine hydrochloride (123486-06-6) + 2-Methoxy-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid isobutyl ester → 2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, 1-[1-(phenylmethyl)-4-piperidinyl]5-(1-methylethyl) ester (108931-62-0)

Guidance literature:

With pyridine; Multistep reaction; 1.) acetonitrile, toluene, RT, 1h, 2.) acetonitrile, toluene, RT, overnight;

DOI:10.1021/jm00095a023

Reference yield:

2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, 1-[1-(phenylmethyl)-4-piperidinyl]5-(1-methylethyl) ester (108931-62-0) → 4-Methyl-6-(3-nitro-phenyl)-2-oxo-3,6-dihydro-2H-pyrimidine-1,5-dicarboxylic acid 1-(1-benzyl-piperidin-4-yl) ester 5-isopropyl ester

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 2h;

DOI:10.1021/jm00095a023

upstream raw materials:

phosgene

1-benzyl-4-hydroxypiperidine hydrochloride

1-benzyl-4-hydroxypiperidine

1,4-Dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid,1-methylethyl ester

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