Z-PHE-MET-OME

Base Information

• Chemical Name: Z-PHE-MET-OME
• CAS No.: 78816-88-3
• Molecular Formula: C23H28 N2 O5 S
• Molecular Weight: 444.54
• Mol file: 78816-88-3.mol

Synonyms:L-Methionine,N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester; N-(Benzyloxycarbonyl)phenylalanylmethioninemethyl ester

Chemical Property of Z-PHE-MET-OME

Chemical Property:

• Vapor Pressure: 7.86E-18mmHg at 25°C
• Refractive Index: 1.569
• Boiling Point: 670.3°C at 760 mmHg
• Flash Point: 359.2°C
• PSA: 119.03000
• Density: 1.208g/cm³
• LogP: 3.71680

Purity/Quality:

98%min ^*data from raw suppliers

Z-PHE-MET-OME 99.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-PHE-MET-OME

There total 10 articles about Z-PHE-MET-OME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Met-OMe (10332-17-9,874219-77-9) + N-Cbz-L-Phe (1161-13-3) → (S)-methyl 2-(((S)-2-(benzyloxy)carbonylamino)-3-phenylpropanamido)-4-(methylthio)butanoate (78816-88-3)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide; 1. 3h 0 deg C 2. overnight in refrigerator;

Reference yield: 68.0%

N-Cbz-L-Phe (1161-13-3) + (S)-methyl 2-(1H-imidazole-1-carboxamido)-4-(methylthio)butanoate (93605-54-0) → (S)-methyl 2-(((S)-2-(benzyloxy)carbonylamino)-3-phenylpropanamido)-4-(methylthio)butanoate (78816-88-3)

Guidance literature:

With benzotriazol-1-ol; copper(ll) bromide; In dichloromethane; at 22 ℃; for 20h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201402147

Reference yield:

(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride (2491-18-1) + (S)-2-Benzyloxycarbonylamino-3-phenyl-propionic acid 4,6-bis-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluoro-nonyloxy)-[1,3,5]triazin-2-yl ester → (S)-methyl 2-(((S)-2-(benzyloxy)carbonylamino)-3-phenylpropanamido)-4-(methylthio)butanoate (78816-88-3)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1055/s-2003-42492

upstream raw materials:

Met-OMe

N-Cbz-L-Phe

(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride

Z-L-phenylalanine DCHA salt

Downstream raw materials:

Cbz-L-Phe-L-Met-OH

Z-Phe-Met-NH_.i-C₃H₇

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