methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate

Base Information

Chemical Name:methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate
CAS No.:60566-44-1
Molecular Formula:C₃₃H₄₅N₅O₉S
Molecular Weight:687.814
Hs Code.:

Synonyms:methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate

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Technology Process of methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate

There total 18 articles about methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3978-80-1
Boc-Tyr-OH

: 70035-46-0
hydrochloride of methyl ester of glycylglycyl-L-phenylalanyl-L-methionine

: 60566-44-1
methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h;
DOI:10.1248/cpb.46.1672

Reference yield: 34.0%

: 64848-07-3
Boc-L-Tyr-Gly-Gly-L-Phe

: 2491-18-1
(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride

: 60566-44-1
methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate

Guidance literature:: With diethyl cyanophosphonate;
DOI:10.1248/cpb.30.1921

Reference yield:

: 70035-45-9
N-tert-Butyloxycarbonyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester

: 60566-44-1
methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 1.5 N HCl/AcOH / 1 h

2: 90 percent / HOBt*H₂O, NEt₃, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h

With hydrogenchloride; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1672