70035-45-9

Basic information

• Product Name: L-Methionine, N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]glycyl]-L-phenylalanyl]-, methyl ester
• CAS NO: 70035-45-9
• Molecular Formula: C24H36N4O7S
• Molecular Weight: 524.638
• Mol File: 70035-45-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: L-Methionine, N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]glycyl]-L-phenylalanyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Methionine, N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]glycyl]-L-phenylalanyl]-, methyl ester(70035-45-9)
• EPA Substance Registry System: L-Methionine, N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]glycyl]-L-phenylalanyl]-, methyl ester(70035-45-9)

Safety Data

• Hazardous Substances Data: 70035-45-9(Hazardous Substances Data)

Upstream product

• 40290-65-1 hydrochloride of methyl ester of L-phenylalanyl-L-methionine 
• 81638-93-9 O-(N-t-butyloxycarbonylglycylglycyl)-2-pyridylmethylketoxime 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 53487-98-2 N-tert-butoxycarbonyl glycyl glycine methyl ester 
• 63-68-3 L-methionine 
• 31972-52-8 Boc-Gly-Gly-OH 
• 69872-63-5 N-(tert-butyloxycarbonyl)glycyl-L-phenylalanyl-L-methionine methyl ester 
• 81638-94-0 O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime 
• 66866-43-1 N-(t-butoxycarbonyl)glycyl i-butyl carbonate 
• 67729-36-6 Boc-Phe-O-COO-isoBu 
• 40290-63-9 Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine 
• 4530-20-5 BOC-glycine 
• 65903-96-0 p-nitrophenyl tert-butoxycarbonylglycylglycinate 
• 7536-61-0 N-(1,1-dimethylethoxycarbonyl)glycine 2,4,5-trichlorophenyl ester 

Downstream Products

• 68709-93-3 H-Gly-Gly-Phe-Met-OMe 
• 68800-26-0 N-tert-butoxycarbonylglycylglycylphenylalanylmethionine 
• 70035-46-0 hydrochloride of methyl ester of glycylglycyl-L-phenylalanyl-L-methionine 
• 62530-43-2 Boc-Tyr(tert.-Bu)-Gly-Gly-Phe-Met 
• 71921-23-8 Boc-Tyr(tert.-Bu)-Gly-Gly-Phe-Met-OMe 
• 97800-86-7 O-tert-Butyl-N,N-dimethyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester 
• 97800-57-2 Me₂Tyr(tBu)-Gly-Gly-Phe-L-Met-NH₂ 
• 97800-59-4 Me₂Tyr-Gly-Gly-Phe-L-Met-NH₂ 
• 73337-50-5 Boc-Gly-Gly-Phe-Met-Thr-Ser-Glu(OtBu)-Lys(Boc)-OH 
• 61370-88-5 [des-tyr¹]-methionine enkephalin 
• 81649-52-7 methyl ester of N,O-di-t-butyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine 
• 58569-55-4 met-enkephalin 
• 60566-44-1 methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate 
• 59481-77-5 boc-Tyr-Gly-Gly-Phe-Met-OH 

Relevant articles and documents

Dynamic Kinetic Cross-Electrophile Arylation of Benzyl Alcohols by Nickel Catalysis

Catalytic transformation of alcohols via metal-catalyzed cross-coupling reactions is very important, but it typically relies on a multistep procedure. We here report a dynamic kinetic cross-coupling approach for the direct functionalization of alcohols. The feasibility of this strategy is demonstrated by a nickel-catalyzed cross-electrophile arylation reaction of benzyl alcohols with (hetero)aryl electrophiles. The reaction proceeds with a broad substrate scope of both coupling partners. The electron-rich, electron-poor, and ortho-/meta-/para-substituted (hetero)aryl electrophiles (e.g., Ar-OTf, Ar-I, Ar-Br, and inert Ar-Cl) all coupled well. Most of the functionalities, including aldehyde, ketone, amide, ester, nitrile, sulfone, furan, thiophene, benzothiophene, pyridine, quinolone, Ar-SiMe3, Ar-Bpin, and Ar-SnBu3, were tolerated. The dynamic nature of this method enables the direct arylation of benzylic alcohol in the presence of various nucleophilic groups, including nonactivated primary/secondary/tertiary alcohols, phenols, and free indoles. It thus offers a robust alternative to existing methods for the precise construction of diarylmethanes. The synthetic utility of the method was demonstrated by a concise synthesis of biologically active molecules and by its application to peptide modification and conjugation. Preliminary mechanistic studies revealed that the reaction of in situ formed benzyl oxalates with nickel, possibly via a radical process, is an initial step in the reaction with aryl electrophiles.

Amino acids and peptides, 50 - Activated N,N-dimethylamino acids. - Synthesis of enkephalines containing N,N-dimethyltyrosine

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Selectivity in the Trimethylsilylation and Acylation of Peptide Bonds, and its Application to Modification of the Enkephalins

N.m.r. spectra of N-acylated peptides, formed by reaction of protected peptides with silylating agents followed by acylation, have provided a means for assessing selectivity in the acylation of amide bonds.Amino-acids such as valine and phenylalanine prev