169280-06-2

Basic information

• Product Name: 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile
• Synonyms: 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile
• CAS NO: 169280-06-2
• Molecular Weight: 213.279
• Mol File: 169280-06-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile(169280-06-2)
• EPA Substance Registry System: 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile(169280-06-2)

Safety Data

• Hazardous Substances Data: 169280-06-2(Hazardous Substances Data)

Usage

Appearance

White to off-white crystalline powder
The compound's visual presentation as a white to off-white crystalline powder.

Molecular weight

237.3 g/mol
The mass of one mole of the compound, which is 237.3 grams.

Usage in pharmaceutical industry

Intermediate in the synthesis of various drugs and active pharmaceutical ingredients
The compound serves as a precursor or building block in the creation of different drugs and active ingredients in the pharmaceutical field.

Usage as a building block

Organic synthesis
The compound is utilized as a fundamental component in the synthesis of other organic compounds.

Toxicity

Low toxicity
The compound is not highly toxic and poses minimal health risks.

Hazard classification

Not classified as hazardous according to regulatory guidelines
The compound does not meet the criteria for being classified as hazardous under the regulations and guidelines set forth by governing bodies.

Upstream product

• 35981-67-0 (4-cyclopropanecarbonyl-phenyl)-acetonitrile 
• 74-88-4 methyl iodide 
• 78-82-0 Isobutyronitrile 
• 6640-25-1 4-chlorophenyl cyclopropyl ketone 
• 772-31-6 cyclopropyl(4-fluorophenyl)methanone 
• 1195-98-8 2-methyl-2-phenylpropionitrile 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 76469-88-0 methyl 4-(cyanomethyl)benzoate 
• 115-46-8 C₁₈H₂₁NO 
• 169032-17-1 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionitrile 
• 394222-37-8 2-(4-(4-hydroxybutanoyl)phenyl)-2-methylpropanenitrile 
• 1308679-43-7 C₁₅H₁₄NO₃^(1-)*Na⁽¹⁺⁾ 
• 1252902-28-5 4-(4-(2-cyanopropan-2-yl)phenyl)-4-oxobutyl 4-methylbenzenesulfonate 
• 394222-38-9 2-(4-(4-bromobutanoyl)phenyl)-2-methylpropanenitrile 

Downstream Products

• 169032-19-3 2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropionitrile 
• 394222-36-7 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile 
• 1319714-86-7 fexofenadine sodium salt 
• 138452-21-8 fexofenadine hydrochloride 
• 162096-54-0 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionic acid 
• 169280-22-2 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionamide 

Relevant articles and documents

Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile

A new process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl- propanenitrile is described. This compound can be used for the production of drugs, such as Fexofenadine.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula whereinW represents —C(=O)— or —CH(OH)—;R1 represents hydrogen or hydroxy;R2 represents hydrogen;R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2;n is an integer of from 1 to 5;m is an integer 0 or 1;R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; andpharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1represents hydrogen or hydroxy; R2represents hydrogen; R1and R2taken together form a second bond between the carbon atoms bearing R1and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1and R2are taken together to form a second bond between the carbon atoms bearing R1and R2or where R1represented hydroxy, m is an integer 0.