169280-06-2

Usage

Appearance

White to off-white crystalline powder
The compound's visual presentation as a white to off-white crystalline powder.

Molecular weight

237.3 g/mol
The mass of one mole of the compound, which is 237.3 grams.

Usage in pharmaceutical industry

Intermediate in the synthesis of various drugs and active pharmaceutical ingredients
The compound serves as a precursor or building block in the creation of different drugs and active ingredients in the pharmaceutical field.

Usage as a building block

Organic synthesis
The compound is utilized as a fundamental component in the synthesis of other organic compounds.

Toxicity

Low toxicity
The compound is not highly toxic and poses minimal health risks.

Hazard classification

Not classified as hazardous according to regulatory guidelines
The compound does not meet the criteria for being classified as hazardous under the regulations and guidelines set forth by governing bodies.

Upstream product

• 78-82-0 Isobutyronitrile 
• 6640-25-1 4-chlorophenyl cyclopropyl ketone 
• 772-31-6 cyclopropyl(4-fluorophenyl)methanone 
• 1195-98-8 2-methyl-2-phenylpropionitrile 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 35981-67-0 (4-cyclopropanecarbonyl-phenyl)-acetonitrile 
• 74-88-4 methyl iodide 
• 76469-88-0 methyl 4-(cyanomethyl)benzoate 
• 115-46-8 C₁₈H₂₁NO 
• 169032-17-1 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionitrile 
• 394222-37-8 2-(4-(4-hydroxybutanoyl)phenyl)-2-methylpropanenitrile 
• 1308679-43-7 C₁₅H₁₄NO₃^(1-)*Na⁽¹⁺⁾ 
• 1252902-28-5 4-(4-(2-cyanopropan-2-yl)phenyl)-4-oxobutyl 4-methylbenzenesulfonate 
• 394222-38-9 2-(4-(4-bromobutanoyl)phenyl)-2-methylpropanenitrile 

Downstream Products

• 138452-21-8 fexofenadine hydrochloride 
• 1319714-86-7 fexofenadine sodium salt 
• 169032-19-3 2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropionitrile 
• 394222-36-7 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile 
• 162096-54-0 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionic acid 
• 169280-22-2 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionamide 

Relevant academic research and scientific papers

Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile

A new process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl- propanenitrile is described. This compound can be used for the production of drugs, such as Fexofenadine.

Processes for the production of fexofenadine

An improved process for the manufacture of fexofenadine is described in which a compound of formula (F): wherein R2 represents COOH, COO—C1-6 alkyl or CN; and R3 represents hydrogen, mesylate, triflate, tosylate or carboxy-C1-6-alkyl, or a salt thereof is prepared by: (I) reacting a compound of formula (B): wherein R1 represents hydrogen or carboxy-C1-6-alkyl; and R2 is a hereinbefore defined, with a copper and/or silver compound in the presence of palladium or a compound thereof to yield a compound of formula (C): wherein R1, and R2 are as hereinbefore defined; (II) converting said compound of formula (C) into a compound of formula (E): wherein R2 and R3 are as hereinbefore defined and R4 represents a halogen atom, and (III) reacting said compound of formula (E) with azacyclonol.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula whereinW represents —C(=O)— or —CH(OH)—;R1 represents hydrogen or hydroxy;R2 represents hydrogen;R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2;n is an integer of from 1 to 5;m is an integer 0 or 1;R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; andpharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula whereinW represents —C(=O)— or —CH(OH)—;R1 represents hydrogen or hydroxy;R2 represents hydrogen;R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2;n is an integer of from 1 to 5;m is an integer 0 or 1;R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof,with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1represents hydrogen or hydroxy; R2represents hydrogen; R1and R2taken together form a second bond between the carbon atoms bearing R1and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1and R2are taken together to form a second bond between the carbon atoms bearing R1and R2or where R1represented hydroxy, m is an integer 0.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents -C(=O)- or -CH(OH)-; R1 represents hydrogen or hydroxy; R2 represents hydrogen; R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3 is -COOH or -COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are ta to form a second bond between the carbon R1 and R2 or where R1 represented hydroxy integer 0.