N^α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

Base Information

• Chemical Name: N^α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine
• CAS No.: 122903-65-5
• Molecular Formula: C₃₁H₅₂N₄O₉Si
• Molecular Weight: 652.861

Synonyms:N^α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

Chemical Property of N^α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

There total 2 articles about N^α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Boc-Lys(Z)-OSu (34404-36-9) + Nε-<<2-(Trimethylsilyl)ethoxy>carbonyl>-L-lysine (85167-75-5) → Nα-α-(tert-butyloxycarbonyl)-Nε-(benzyloxycarbonyl)-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine (122903-65-5)

Guidance literature:

With Etifelmin; In N,N-dimethyl-formamide; at 25 ℃; for 120h;

DOI:10.1021/jo00284a031

Reference yield:

Boc-Lys(Z)-OH (2389-45-9) → Nα-α-(tert-butyloxycarbonyl)-Nε-(benzyloxycarbonyl)-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine (122903-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / DCC / 1.) EtOAc, 25 deg C, 3 h, 2.) Et₂O, overnight

2: 92 percent / EDPA / dimethylformamide / 120 h / 25 °C

With Etifelmin; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jo00284a031

Reference yield: 98.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Nα-α-(tert-butyloxycarbonyl)-Nε-(benzyloxycarbonyl)-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine (122903-65-5) → Nα-α-(tert-butyloxycarbonyl)-Nε-(benzyloxycarbonyl)-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine N-hydroxysuccinimide ester (122903-66-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; at 25 - 30 ℃; for 72h;

DOI:10.1021/jo00284a031

upstream raw materials:

Boc-Lys(Z)-OSu

N^ε-<<2-(Trimethylsilyl)ethoxy>carbonyl>-L-lysine

Boc-Lys(Z)-OH

Downstream raw materials:

N^α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine N-hydroxysuccinimide ester

N^α-α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 122903-65-5 N^α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

Send

Send

Metric Ton KG G Pound L ML

Send

Send