2-[2-(1,3-dioxolan-2-yl)-2-methylpropyl]-4-fluorobenzenesulfonyl chloride

Base Information

• Chemical Name: 2-[2-(1,3-dioxolan-2-yl)-2-methylpropyl]-4-fluorobenzenesulfonyl chloride
• CAS No.: 1609201-05-9
• Molecular Formula: C₁₃H₁₆ClFO₄S
• Molecular Weight: 322.785
• Mol file: 1609201-05-9.mol

Synonyms:2-[2-(1,3-dioxolan-2-yl)-2-methylpropyl]-4-fluorobenzenesulfonyl chloride

Chemical Property of 2-[2-(1,3-dioxolan-2-yl)-2-methylpropyl]-4-fluorobenzenesulfonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(1,3-dioxolan-2-yl)-2-methylpropyl]-4-fluorobenzenesulfonyl chloride

There total 2 articles about 2-[2-(1,3-dioxolan-2-yl)-2-methylpropyl]-4-fluorobenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-5-fluorobenzyl bromide (112399-50-5) → 2-[2-(1,3-dioxolan-2-yl)-2-methylpropyl]-4-fluorobenzenesulfonyl chloride (1609201-05-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium hydroxide / toluene / 20 h / 60 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark; Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 - 20 °C

3.3: 0.5 h / 20 °C

With n-butyllithium; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; hexane; toluene;

Reference yield:

3-(2-bromo-5-fluorophenyl)-2,2-dimethylpropanal (1609201-07-1) → 2-[2-(1,3-dioxolan-2-yl)-2-methylpropyl]-4-fluorobenzenesulfonyl chloride (1609201-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 - 20 °C

2.3: 0.5 h / 20 °C

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; toluene;

Reference yield:

methyl (1aR,7bS)-5-amino-1,1 a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate (1412976-22-7) + 2-[2-(1,3-dioxolan-2-yl)-2-methylpropyl]-4-fluorobenzenesulfonyl chloride (1609201-05-9) → methyl (1aR,7bS)-5-{2-[2-(1,3-dioxolan-2-yl)-2-methylpropyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate (1609201-04-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 17h;

upstream raw materials:

2-bromo-5-fluorobenzyl bromide

3-(2-bromo-5-fluorophenyl)-2,2-dimethylpropanal

Downstream raw materials:

methyl (1aR,7bS)-5-{2-[2-(1,3-dioxolan-2-yl)-2-methylpropyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate

methyl (1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

(1aR,7bS)-5-[2-(3-diethylamino-2,2-dimethylpropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

methyl (1aR,7bS)-5-[2-(2,2-dimethyl-3-oxopropyl)-4-fluorobenzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate