amino-2 chloro-5 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine

Base Information

• Chemical Name: amino-2 chloro-5 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine
• CAS No.: 76853-90-2
• Molecular Formula: C₁₀H₈ClN₃O₂
• Molecular Weight: 237.645
• Mol file: 76853-90-2.mol

Synonyms:amino-2 chloro-5 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine

Chemical Property of amino-2 chloro-5 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of amino-2 chloro-5 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine

There total 4 articles about amino-2 chloro-5 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

3-chloro-4-methoxy-2H-chromen-2-one (76853-89-9) + guanidine hydrochloride (50-01-1) → amino-2 chloro-5 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine (76853-90-2)

Guidance literature:

With sodium ethanolate; In ethanol; for 7h; Heating;

Reference yield:

amino-2 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine (29360-84-7) → amino-2 chloro-5 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine (76853-90-2)

Guidance literature:

With N-chloro-succinimide; In acetic acid; at 90 ℃; for 2h;

DOI:10.1021/jm00150a018

Reference yield:

3-(2-hydroxyphenyl)-3-oxopropanoate ethyl ester (23008-77-7) → amino-2 chloro-5 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine (76853-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; toluene / Heating

2: N-chlorosuccinimide / acetic acid / 2 h / 90 °C

With N-chloro-succinimide; In ethanol; acetic acid; toluene;

DOI:10.1021/jm00150a018

upstream raw materials:

3-chloro-4-methoxy-2H-chromen-2-one

guanidine hydrochloride

amino-2 (hydroxy-2 phenyl)-6 oxo-4 dihydro-3,4 pyrimidine

3-(2-hydroxyphenyl)-3-oxopropanoate ethyl ester