2-(3,5-bistrifluoromethylphenyl)methyl propionate

Base Information

• Chemical Name: 2-(3,5-bistrifluoromethylphenyl)methyl propionate
• CAS No.: 374794-36-2
• Molecular Formula: C₁₂H₁₀F₆O₂
• Molecular Weight: 300.201
• Mol file: 374794-36-2.mol

Synonyms:2-(3,5-bistrifluoromethylphenyl)methyl propionate

Chemical Property of 2-(3,5-bistrifluoromethylphenyl)methyl propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-bistrifluoromethylphenyl)methyl propionate

There total 3 articles about 2-(3,5-bistrifluoromethylphenyl)methyl propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 2-(3,5-bis(trifluoromethyl)phenyl)acrylate (334477-28-0) → 2-(3,5-bistrifluoromethylphenyl)methyl propionate (374794-36-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; for 1h; under 2585.81 Torr;

Reference yield:

3,5-bis(trifluoromethyl)styrene (349-59-7) → 2-(3,5-bistrifluoromethylphenyl)methyl propionate (374794-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: C₈₄H₄₈Cl₂F₃₆P₄Rh₂; N-ethyl-N,N-diisopropylamine; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; caesium carbonate / N,N-dimethyl acetamide / 24 h / 20 °C / 760.05 Torr / Inert atmosphere; Irradiation

2: methanol; diethyl ether / 0.5 h / 0 °C

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; C₈₄H₄₈Cl₂F₃₆P₄Rh₂; caesium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; N,N-dimethyl acetamide;

DOI:10.1039/c7cc00678k

Reference yield:

methyl [3,5-bis(trifluoromethyl)-phenyl]-acetate (95299-16-4) + methyl iodide (74-88-4) → 2-(3,5-bistrifluoromethylphenyl)methyl propionate (374794-36-2)

Guidance literature:

methyl [3,5-bis(trifluoromethyl)-phenyl]-acetate; With sodium hydride; In tetrahydrofuran; at -20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 16h;

upstream raw materials:

methyl 2-(3,5-bis(trifluoromethyl)phenyl)acrylate

methyl [3,5-bis(trifluoromethyl)-phenyl]-acetate

methyl iodide

3,5-bis(trifluoromethyl)styrene

Downstream raw materials:

(RS)-α-Methyl-3,5-bis(trifluoromethyl)benzeneacetic Acid