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Usage

Uses

Used in Chemical Synthesis:
3,5-BIS(TRIFLUOROMETHYL)STYRENE is used as a chemical intermediate for the production of other chemicals, such as 1-(3, 5-bis-Trifluoromethyl-phenyl)-ethane-1, 2-diol. Its unique structure and reactivity make it a versatile building block in the synthesis of various compounds with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,5-BIS(TRIFLUOROMETHYL)STYRENE can be used as a starting material for the development of new drugs with specific therapeutic properties. Its unique chemical structure may contribute to the design of novel molecules with improved pharmacological profiles.
Used in Polymer Industry:
3,5-BIS(TRIFLUOROMETHYL)STYRENE can also be utilized in the polymer industry as a monomer for the synthesis of polymers with specific properties, such as enhanced thermal stability, chemical resistance, or mechanical strength. These polymers can find applications in various sectors, including automotive, electronics, and aerospace.
Used in Agrochemical Industry:
In the agrochemical industry, 3,5-BIS(TRIFLUOROMETHYL)STYRENE may be employed as a precursor for the development of new pesticides or other agrochemical products. Its unique chemical structure could potentially lead to the creation of more effective and environmentally friendly solutions for pest control and crop protection.
Overall, 3,5-BIS(TRIFLUOROMETHYL)STYRENE is a versatile compound with a wide range of potential applications across various industries, including chemical synthesis, pharmaceuticals, polymers, and agrochemicals. Its unique structure and reactivity make it a valuable intermediate for the development of new products and materials with improved properties and performance.

InChI:InChI=1/C10H6F6/c1-2-6-3-7(9(11,12)13)5-8(4-6)10(14,15)16/h2-5H,1H2

Upstream product

• 68120-60-5 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol 
• 74-85-1 ethene 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 367922-41-6 methanesulfonic acid (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl ester 
• 190269-75-1 methyl (1R,2R,3S)-2-(4-fluorophenyl)-3-hydroxycyclopentane-1-carboxylate 
• 88444-81-9 3,5-bis(trifluoromethyl)phenylacetylene 
• 849674-12-0 (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl-2,2,2-trichloroethanimidoate 
• 1021816-97-6 C₁₄H₁₇FO₂ 

Downstream Products

• 297171-85-8 (S)-1-(3,5-bis(trifluoromethyl)phenyl)-1,2-ethanediol 
• 381211-15-0 (S)-2-imino[1-(bis-3,5-(trifluoromethyl)phenyl)ethanol]-2'-ethanol 
• 374822-25-0 (RS)-1-[3,5-Bis(trifluoromethyl)phenyl]-1.2-ethanediol 
• 634187-22-7 5-chloro-2-methoxy-β-[3,5-bis(trifluoromethyl)phenyl]styrene 
• 93427-28-2 3,5-Bis(trifluoromethyl)-β-phenethyl alcohol 
• 68120-60-5 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol 

Relevant academic research and scientific papers

In-situ facile synthesis novel N-doped thin graphene layer encapsulated Pd@N/C catalyst for semi-hydrogenation of alkynes

Transition metal-catalyzed semi-hydrogenation of alkynes has become one of the most popular methods for alkene synthesis. Specifically, the noble metal Pd, Rh, and Ru-based heterogeneous catalysts have been widely studied and utilized in both academia and industry. But the supported noble metal catalysts are generally suffering from leaching or aggregation during harsh reaction conditions, which resulting low catalytic reactivity and stability. Herein, we reported the facile synthesis of nitrogen doped graphene encapsulated Pd catalyst and its application in the chemo-selective semi-hydrogenation of alkynes. The graphene layer served as “bulletproof” over the active Pd Nano metal species, which was confirmed by X-ray and TEM analysis, enhanced the catalytic stability during the reaction conditions. The optimized prepared Pd@N/C catalyst showed excellent efficiency in semi-hydrogenation of phenylacetylene and other types of alkynes with un-functionalized or functionalized substituents, including the hydrogenation sensitive functional groups (NO2, ester, and halogen).

Synthesis and characterization of trifluoromethyl substituted styrene polymers and copolymers with methacrylates: Effects of trifluoromethyl substituent on styrene

2-Trifluoromethyl styrene (2TFMS), 2,5-bis(trifluoromethyl) styrene (25BTFMS), and 3,5-bis(trifluoromethyl) styrene (35BTFMS) were synthesized. These styrenes were readily polymerized in bulk and also in solution using AIBN as a free radical initiator. The polymerization rate of these trifluoromethyl substituted styrenes and other monomers such as styrene (St), pentafluorostyrene (PFS) and 4-trifluoromethyl-tetrafluorostyrene (TFMTFS) were measured in benzene and dioxane by monitoring the 1H NMR spectra of the double bond hydrogen. The order of polymerization rates was TFMTFS > 35BTFMS > 25BTFMS > PFS > 2TFMS > St. Tgs of styrene polymers with CF3 substituted on the ortho position of the phenyl ring were much higher than those of the meta and para substituted styrenes due to the steric hindrance of the bulky CF3 group close to the polymer main chain, which resulted in a decrease in the segment mobility of the polymer chains and an increasing Tg of the polymers. The copolymers of 2TFMS with methyl methacrylate (MMA) and also 25BTFMS with trifluoroethyl methacrylate (TFEMA) were prepared. Tgs of the copolymers were in the range of 120-145 °C and the copolymers were transparent and thermally stable. The copolymer films were flexible and exhibited high transmittance as the homopolymers of MMA and TFEMA. Thus, these copolymers may be utilized as novel optical materials.

Process for making hydroisoindoline tachykinin receptor antagonists

The present invention is directed to a process for preparing certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

Stereoselective preparation of a cyclopentane-based NK1 receptor antagonist bearing an unsymmetrically substituted sec-sec ether

A highly efficient synthesis of the potent and selective NK-1 receptor antagonist 1 is described. The key transformation involved the etherification reaction between cyclopentanol 12 and chiral imidate 30 which was catalyzed by HBF4 to initially give ether 14 as a 17:1 mixture of diastereomers and in 75% combined yield. The diastereoselectivity was upgraded to 109:1 by crystallization of the triethylamine solvate 44 which was isolated in 54% yield from 12. Mechanistic studies confirmed that the etherification reaction proceeds through an unprecedented SN2 reaction pathway under typical S N1 reaction conditions.

Crystallization-induced diastereoselection: Asymmetric synthesis of substance P inhibitors

A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.

Intramolecular glycosidation process for the synthesis of (2R, 2-alpha-R, 3A)-2-[1-(3,5- BIS (trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine

The present invention is concerned with novel processes for the preparation of (2R-cis)-2-[[1 -[3.5-bis(trifluoromethyl)phenyl]ethenyl] oxy]-3-(4-fluorophenyl)-4-(phenylmethyl)mopholine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.