349-59-7

Basic information

• Product Name: 3,5-BIS(TRIFLUOROMETHYL)STYRENE
• Synonyms: 3,5-BIS(TRIFLUOROMETHYL)STYRENE;3,5-Bis(trifluoromethyl)styrene 98%;3,5-Bis(trifluoromethyl)styrene98%;3,5-BIS(TRIFLUOROMETHYL)STYRENE , STABILIZED WITH MEHQ;3,5-BIS(TRIFLUOROMETHYL)STYRENE, 98%, STAB. WITH 4-METHOXYPH;3,5-Bis(trifluoromethyl)styrene, 98%, stab. with 4-methoxyphenol;3,5-Bis(trifluoromethyl)styrene, 98%, stab. with MEHQ;3,5-Bis(trifluoromethyl)styrene, 98%, stab.
• CAS NO: 349-59-7
• Molecular Formula: C₁₀H₆F₆
• Molecular Weight: 240.15
• Product Categories: Miscellaneous
• Mol File: 349-59-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 7-8 °C(lit.)
• Boiling Point: 60 °C20 mm Hg(lit.)
• Flash Point: 122 °F
• Appearance: /
• Density: 1.334 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.61mmHg at 25°C
• Refractive Index: n20/D 1.425(lit.)
• Storage Temp.: 2-8°C
• Water Solubility: Sparingly soluble in water.
• CAS DataBase Reference: 3,5-BIS(TRIFLUOROMETHYL)STYRENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-BIS(TRIFLUOROMETHYL)STYRENE(349-59-7)
• EPA Substance Registry System: 3,5-BIS(TRIFLUOROMETHYL)STYRENE(349-59-7)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 349-59-7(Hazardous Substances Data)

Usage

Uses

3,5-Bis(trifluoromethyl)styrene is used to produce other chemicals for example 1-(3, 5-bis-Trifluoromethyl-phenyl)-ethane-1, 2-diol.

InChI:InChI=1/C10H6F6/c1-2-6-3-7(9(11,12)13)5-8(4-6)10(14,15)16/h2-5H,1H2

Upstream product

• 68120-60-5 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol 
• 74-85-1 ethene 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 367922-41-6 methanesulfonic acid (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl ester 
• 190269-75-1 methyl (1R,2R,3S)-2-(4-fluorophenyl)-3-hydroxycyclopentane-1-carboxylate 
• 849674-12-0 (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl-2,2,2-trichloroethanimidoate 
• 1021816-97-6 C₁₄H₁₇FO₂ 
• 88444-81-9 3,5-bis(trifluoromethyl)phenylacetylene 

Downstream Products

• 374822-25-0 (RS)-1-[3,5-Bis(trifluoromethyl)phenyl]-1.2-ethanediol 
• 93427-28-2 3,5-Bis(trifluoromethyl)-β-phenethyl alcohol 
• 68120-60-5 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol 
• 1315258-41-3 2-(3,5-bis(trifluoromethyl)phenyl)-1-phenylpropan-1-one 
• 374794-36-2 2-(3,5-bistrifluoromethylphenyl)methyl propionate 
• 289686-73-3 (RS)-α-Methyl-3,5-bis(trifluoromethyl)benzeneacetic Acid 
• 848863-57-0 (E,E)-1,4-di-(3,5-bis(trifluoromethyl)phenyl)-1,3-butadiene 

Relevant articles and documents

In-situ facile synthesis novel N-doped thin graphene layer encapsulated Pd@N/C catalyst for semi-hydrogenation of alkynes

Transition metal-catalyzed semi-hydrogenation of alkynes has become one of the most popular methods for alkene synthesis. Specifically, the noble metal Pd, Rh, and Ru-based heterogeneous catalysts have been widely studied and utilized in both academia and industry. But the supported noble metal catalysts are generally suffering from leaching or aggregation during harsh reaction conditions, which resulting low catalytic reactivity and stability. Herein, we reported the facile synthesis of nitrogen doped graphene encapsulated Pd catalyst and its application in the chemo-selective semi-hydrogenation of alkynes. The graphene layer served as “bulletproof” over the active Pd Nano metal species, which was confirmed by X-ray and TEM analysis, enhanced the catalytic stability during the reaction conditions. The optimized prepared Pd@N/C catalyst showed excellent efficiency in semi-hydrogenation of phenylacetylene and other types of alkynes with un-functionalized or functionalized substituents, including the hydrogenation sensitive functional groups (NO2, ester, and halogen).

Process for making hydroisoindoline tachykinin receptor antagonists

The present invention is directed to a process for preparing certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

Crystallization-induced diastereoselection: Asymmetric synthesis of substance P inhibitors

A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.