1-[2-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenyl)-(E)-vinyl]-cycloheptanol

Base Information

Chemical Name:1-[2-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenyl)-(E)-vinyl]-cycloheptanol
CAS No.:917026-25-6
Molecular Formula:C₃₄H₄₉BO₃
Molecular Weight:516.572
Hs Code.:

Synonyms:1-[2-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenyl)-(E)-vinyl]-cycloheptanol

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Chemical Property of 1-[2-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenyl)-(E)-vinyl]-cycloheptanol

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Technology Process of 1-[2-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenyl)-(E)-vinyl]-cycloheptanol

There total 7 articles about 1-[2-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenyl)-(E)-vinyl]-cycloheptanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 917026-24-5
trifluoromethanesulfonic acid 4-(1-ethyl-1-{4-[2-(1-hydroxy-cycloheptyl)-(E)-vinyl]-3-methyl-phenyl}-propyl)-2-methyl-phenyl ester

: 73183-34-3
bis(pinacol)diborane

: 917026-25-6
1-[2-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenyl)-(E)-vinyl]-cycloheptanol

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 100 ℃; for 2.25h;

Reference yield:

: 865235-91-2
4-[1-ethyl-1-(4-ethynyl-3-methylphenyl)-propyl]-2-methylphenol

: 917026-25-6
1-[2-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenyl)-(E)-vinyl]-cycloheptanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2 h / 0 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran; dichloromethane / 2.5 h / 0 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2.25 h / 100 °C

With n-butyllithium; potassium acetate; sodium hexamethyldisilazane; sodium bis(2-methoxyethoxy)aluminium dihydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 865235-89-8
trifluoromethanesulfonic acid 4-[1-ethyl-1-(4-hydroxy-3-methylphenyl)-propyl]-2-methylphenyl ester

: 917026-25-6
1-[2-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenyl)-(E)-vinyl]-cycloheptanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 18 h / 110 °C

1.2: pH 7

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / 0 °C

3.2: 2 h / 0 - 20 °C

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2 h / 0 °C

5.1: sodium hexamethyldisilazane / tetrahydrofuran; dichloromethane / 2.5 h / 0 °C

6.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2.25 h / 100 °C

With n-butyllithium; tetrabutyl ammonium fluoride; potassium acetate; sodium hexamethyldisilazane; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;