ethyl 6-{4-[trans-4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxylate

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Chemical Name:ethyl 6-{4-[trans-4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxylate
CAS No.:1166827-47-9
Molecular Formula:C₂₇H₃₆N₂O₄
Molecular Weight:452.594
Hs Code.:

Synonyms:ethyl 6-{4-[trans-4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxylate

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Chemical Property of ethyl 6-{4-[trans-4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxylate

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Technology Process of ethyl 6-{4-[trans-4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxylate

There total 10 articles about ethyl 6-{4-[trans-4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1166827-48-0
ethyl 6-chloro-3,5-dimethylpyrazine-2-carboxylate

: 1166827-54-8
tert-butyl {trans-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclohexyl}acetate

: 1166827-47-9
ethyl 6-{4-[trans-4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxylate

Guidance literature:: With potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; ethanol; water; at 140 ℃; for 0.833333h; Microwave irradiation;

Reference yield:

: 1166827-50-4
ethyl 2-{[N-(tert-butoxycarbonyl)-L-alanyl]amino}-3-oxobutanoate

: 1166827-47-9
ethyl 6-{4-[trans-4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 1,2-dichloro-ethane / 4 h / Heating

2: trichlorophosphate / propyl cyanide / 0.17 h / 150 °C / Microwave irradiation

3: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; ethanol; water / 0.83 h / 140 °C / Microwave irradiation

With potassium phosphate; trifluoroacetic acid; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; propyl cyanide; ethanol; water; 1,2-dichloro-ethane;

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1166827-47-9
ethyl 6-{4-[trans-4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 6 h / 20 °C

2: rhodium (II) octanoate dimer / toluene / 80 °C

3: trifluoroacetic acid / 1,2-dichloro-ethane / 4 h / Heating

4: trichlorophosphate / propyl cyanide / 0.17 h / 150 °C / Microwave irradiation

5: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; ethanol; water / 0.83 h / 140 °C / Microwave irradiation

With potassium phosphate; triethylamine; trifluoroacetic acid; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; rhodium (II) octanoate dimer; In 1,2-dimethoxyethane; propyl cyanide; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene;