methyl 2-[6-(4-methoxyphenyl)indolo[1,2-a]quinoxalin-1-yl]-1-(2-methylpropyl)-1H-benzimidazole-5-carboxylate

Base Information

Chemical Name:methyl 2-[6-(4-methoxyphenyl)indolo[1,2-a]quinoxalin-1-yl]-1-(2-methylpropyl)-1H-benzimidazole-5-carboxylate
CAS No.:1383812-65-4
Molecular Formula:C₃₅H₃₀N₄O₃
Molecular Weight:554.648
Hs Code.:

Synonyms:methyl 2-[6-(4-methoxyphenyl)indolo[1,2-a]quinoxalin-1-yl]-1-(2-methylpropyl)-1H-benzimidazole-5-carboxylate

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Chemical Property of methyl 2-[6-(4-methoxyphenyl)indolo[1,2-a]quinoxalin-1-yl]-1-(2-methylpropyl)-1H-benzimidazole-5-carboxylate

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Technology Process of methyl 2-[6-(4-methoxyphenyl)indolo[1,2-a]quinoxalin-1-yl]-1-(2-methylpropyl)-1H-benzimidazole-5-carboxylate

There total 9 articles about methyl 2-[6-(4-methoxyphenyl)indolo[1,2-a]quinoxalin-1-yl]-1-(2-methylpropyl)-1H-benzimidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1383811-59-3
methyl 2-(3-amino-2-(1H-indol-1-yl)phenyl)-1-isobutyl-1H-benzo[d]imidazole-5-carboxylate

: 123-11-5
4-methoxy-benzaldehyde

: 1383812-65-4
methyl 2-[6-(4-methoxyphenyl)indolo[1,2-a]quinoxalin-1-yl]-1-(2-methylpropyl)-1H-benzimidazole-5-carboxylate

Guidance literature:: With magnesium sulfate; trifluoroacetic acid; In chloroform; for 14h; Reflux; Inert atmosphere;
DOI:10.1002/asia.201200121

Reference yield:

: 1383811-53-7
methyl 2-(2-(indolin-1-yl)-3-nitrophenyl)-1-isobutyl-1H-benzo[d]imidazole-5-carboxylate

: 1383812-65-4
methyl 2-[6-(4-methoxyphenyl)indolo[1,2-a]quinoxalin-1-yl]-1-(2-methylpropyl)-1H-benzimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 6 h / 20 °C / Inert atmosphere

2: ammonium formate; zinc / methanol / 0.17 h / 20 °C / Inert atmosphere

3: magnesium sulfate; trifluoroacetic acid / chloroform / 14 h / Reflux; Inert atmosphere

With ammonium formate; magnesium sulfate; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; In methanol; dichloromethane; chloroform; 3: Pictet-Spengler-type cyclization reaction;
DOI:10.1002/asia.201200121

Reference yield:

: 1383811-49-1
methyl 3-(2-chloro-3-nitrobenzamido)-4-(isobutylamino)benzoate

: 1383812-65-4
methyl 2-[6-(4-methoxyphenyl)indolo[1,2-a]quinoxalin-1-yl]-1-(2-methylpropyl)-1H-benzimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: magnesium sulfate; trifluoroacetic acid / 1,2-dichloro-ethane / Inert atmosphere

2: 4 h / 150 °C / Inert atmosphere

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 6 h / 20 °C / Inert atmosphere

4: ammonium formate; zinc / methanol / 0.17 h / 20 °C / Inert atmosphere

5: magnesium sulfate; trifluoroacetic acid / chloroform / 14 h / Reflux; Inert atmosphere

With ammonium formate; magnesium sulfate; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; In methanol; dichloromethane; chloroform; 1,2-dichloro-ethane; 5: Pictet-Spengler-type cyclization reaction;
DOI:10.1002/asia.201200121