2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester

Base Information

Chemical Name:2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester
CAS No.:1052722-43-6
Molecular Formula:C₁₇H₁₆F₂O₅S
Molecular Weight:370.374
Hs Code.:

Synonyms:2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester

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Chemical Property of 2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester

Chemical Property:

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Technology Process of 2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester

There total 4 articles about 2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1052722-21-0
2-bromo-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester

: 367-27-1
2,4-difluorophenol

: 1052722-43-6
2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 - 70 ℃; for 2 - 3h;

Reference yield:

: 1052722-20-9
2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester

: 1052722-43-6
2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 1 h / Heating / reflux

2: potassium carbonate / N,N-dimethyl-formamide / 2 - 3 h / 60 - 70 °C

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

: 90536-66-6
4-(methylsulfonyl)phenylacetic acid

: 1052722-43-6
2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 24 h / Heating / reflux

2.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; diisopropylamine / tetrahydrofuran / 1.5 h / -78 °C

2.2: -78 - 20 °C

3.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 1 h / Heating / reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 - 3 h / 60 - 70 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N-Bromosuccinimide; n-butyllithium; potassium carbonate; diisopropylamine; sulfuric acid; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;