N-(2-methoxyphenyl)-4-nitrobenzenesulfonamide

Base Information

• Chemical Name: N-(2-methoxyphenyl)-4-nitrobenzenesulfonamide
• CAS No.: 299968-56-2
• Molecular Formula: C₁₃H₁₂N₂O₅S
• Molecular Weight: 308.315
• Mol file: 299968-56-2.mol

Synonyms:N-(2-methoxyphenyl)-4-nitro-benzenesulfonamide

Chemical Property of N-(2-methoxyphenyl)-4-nitrobenzenesulfonamide

Chemical Property:

Purity/Quality:

N-(2-methoxyphenyl)-4-nitrobenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-methoxyphenyl)-4-nitrobenzenesulfonamide

There total 1 articles about N-(2-methoxyphenyl)-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-methoxy-phenylamine (90-04-0) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → N-(2-methoxyphenyl)-4-nitro-benzenesulfonamide (299968-56-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 24h;

Reference yield: 84.0%

N-(2-methoxyphenyl)-4-nitro-benzenesulfonamide (299968-56-2) → 4-amino-N-(2-methoxyphenyl)-benzenesulfonamide (19837-84-4)

Guidance literature:

With iron; ammonium chloride; In methanol; water; at 65 ℃; for 24h;

Reference yield: 76.0%

4-toluenesulfonyl azide (941-55-9) + N-(2-methoxyphenyl)-4-nitro-benzenesulfonamide (299968-56-2) + phenylacetylene (536-74-3) → N-[1-(2-methoxyphenylamino)-2-(4-nitrophenyl)-2-phenylethylidene]-4-methylbenzenesulfonamide

Guidance literature:

With triethylamine; copper(I) bromide; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201800490

upstream raw materials:

2-methoxy-phenylamine

4-Nitrobenzenesulfonyl chloride

Downstream raw materials:

4-amino-N-(2-methoxyphenyl)-benzenesulfonamide

Refernces

• 1、 -. "INHIBITORS OF RAC1 AND USES THEREOF FOR INDUCING BRONCHODILATATION". Paragraph 0068; 0069. . Retrieved 2019/01/04.
• 2、 Lawrence, Harshani R.,Kazi, Aslamuzzaman,Luo, Yunting,Kendig, Robert,Ge, Yiyu,Jain, Sanjula,Daniel, Kenyon,Santiago, Daniel,Guida, Wayne C.,Sebti, Said M.. "Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors". experimental part. p. 5576 - 5592. Retrieved 2010/09/15.