2-(4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenoxy)-2-methylpropanoic acid ethyl ester

Base Information

Chemical Name:2-(4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenoxy)-2-methylpropanoic acid ethyl ester
CAS No.:444613-82-5
Molecular Formula:C₃₅H₃₈F₃N₃O₄S₂
Molecular Weight:685.832
Hs Code.:

2-(4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenoxy)-2-methylpropanoic acid ethyl ester

Synonyms:2-(4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenoxy)-2-methylpropanoic acid ethyl ester

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Chemical Property of 2-(4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenoxy)-2-methylpropanoic acid ethyl ester

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Technology Process of 2-(4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenoxy)-2-methylpropanoic acid ethyl ester

There total 9 articles about 2-(4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenoxy)-2-methylpropanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 444613-51-8
ethyl 2-{4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}-2-methylpropanoate

: 38212-30-5
4-(4-methoxyphenyl)piperazine

: 124-63-0
methanesulfonyl chloride

: 444613-82-5
2-(4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenoxy)-2-methylpropanoic acid ethyl ester

Guidance literature:: With N₂; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 444613-23-4
ethyl 2-methyl-2-(4-sulfanylphenoxy)propanoate

: 444613-82-5
2-(4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenoxy)-2-methylpropanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 273.2 g / isopropyl acetate; 1,2-dimethoxy-ethane; H₂O / 3 h / 89 °C

2: triethylamine

With triethylamine; In 1,2-dimethoxyethane; Isopropyl acetate; water;
DOI:10.1021/jo061295n

Reference yield:

: 444613-21-2
ethyl 2-[4-(chlorosulfonyl)phenoxy]-2-methylpropanoate

: 444613-82-5
2-(4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenoxy)-2-methylpropanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Zn; dichlorodimethylsilane / isopropyl acetate; 1,2-dimethoxy-ethane; H₂O / 60 °C

2: 273.2 g / isopropyl acetate; 1,2-dimethoxy-ethane; H₂O / 3 h / 89 °C

3: triethylamine

With triethylamine; dimethylsilicon dichloride; zinc; In 1,2-dimethoxyethane; Isopropyl acetate; water;
DOI:10.1021/jo061295n