ethyl 2-{4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}-2-methylpropanoate

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Chemical Name:ethyl 2-{4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}-2-methylpropanoate
CAS No.:444613-51-8
Molecular Formula:C₂₄H₂₄F₃NO₄S₂
Molecular Weight:511.586
Hs Code.:

Synonyms:ethyl 2-{4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}-2-methylpropanoate

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Chemical Property of ethyl 2-{4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}-2-methylpropanoate

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Technology Process of ethyl 2-{4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}-2-methylpropanoate

There total 5 articles about ethyl 2-{4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 444613-21-2
ethyl 2-[4-(chlorosulfonyl)phenoxy]-2-methylpropanoate

: 444613-51-8
ethyl 2-{4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: Zn; dichlorodimethylsilane / isopropyl acetate; 1,2-dimethoxy-ethane; H₂O / 60 °C

2: 273.2 g / isopropyl acetate; 1,2-dimethoxy-ethane; H₂O / 3 h / 89 °C

With dimethylsilicon dichloride; zinc; In 1,2-dimethoxyethane; Isopropyl acetate; water;
DOI:10.1021/jo061295n

Reference yield:

: 444615-63-8
diethyl 2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4,5-dicarboxylate

: 444613-51-8
ethyl 2-{4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / lithium aluminium hydride / tetrahydrofuran / 1 h / -15 - -10 °C

2: 273.2 g / isopropyl acetate; 1,2-dimethoxy-ethane; H₂O / 3 h / 89 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; 1,2-dimethoxyethane; Isopropyl acetate; water;
DOI:10.1021/jo061295n

Reference yield:

: 72505-21-6
4-trifluoromethylbenzthioamide

: 444613-51-8
ethyl 2-{4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / ethanol / 6 h / 67 - 69 °C

2: 81 percent / lithium aluminium hydride / tetrahydrofuran / 1 h / -15 - -10 °C

3: 273.2 g / isopropyl acetate; 1,2-dimethoxy-ethane; H₂O / 3 h / 89 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; Isopropyl acetate; water;
DOI:10.1021/jo061295n