ethyl 6-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

Base Information

Chemical Name:ethyl 6-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate
CAS No.:1282619-42-4
Molecular Formula:C₁₅H₁₄FNO₄
Molecular Weight:291.279
Hs Code.:

Synonyms:ethyl 6-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

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Chemical Property of ethyl 6-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

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Technology Process of ethyl 6-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

There total 4 articles about ethyl 6-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 604000-41-1
ethyl-3-amino-4-(4-fluorophenyl)-2-butenoate

: 105-53-3
diethyl malonate

: 1282619-42-4
ethyl 6-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: diethyl malonate; With sodium; In ethanol; for 1h;

ethyl-3-amino-4-(4-fluorophenyl)-2-butenoate; In ethanol; for 96h; Reflux;
DOI:10.1021/jm400102x

Reference yield:

: 221121-37-5
4-(4-fluorophenyl)-3-oxobutanoic acid ethyl ester

: 1282619-42-4
ethyl 6-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia / methanol / 8 h / Reflux; Sealed tube

2.1: sodium / ethanol / 1 h

2.2: 96 h / Reflux

With ammonia; sodium; In methanol; ethanol;
DOI:10.1021/jm400102x

Reference yield:

: 459-04-1
4-Fluorophenylacetyl chloride

: 1282619-42-4
ethyl 6-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 8.5 h / 0 - 20 °C

2.1: 4 h / Reflux

3.1: ammonia / methanol / 8 h / Reflux; Sealed tube

4.1: sodium / ethanol / 1 h

4.2: 96 h / Reflux

With pyridine; ammonia; sodium; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm400102x