diphenyl-((2S,4R)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yl-oxy)ethyl]benzyloxy}pyrrolidin-2-yl)methanol

Base Information

• Chemical Name: diphenyl-((2S,4R)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yl-oxy)ethyl]benzyloxy}pyrrolidin-2-yl)methanol
• CAS No.: 1061611-27-5
• Molecular Formula: C₃₅H₄₆N₂O₃
• Molecular Weight: 542.762
• Mol file: 1061611-27-5.mol

Synonyms:diphenyl-((2S,4R)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yl-oxy)ethyl]benzyloxy}pyrrolidin-2-yl)methanol

Chemical Property of diphenyl-((2S,4R)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yl-oxy)ethyl]benzyloxy}pyrrolidin-2-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diphenyl-((2S,4R)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yl-oxy)ethyl]benzyloxy}pyrrolidin-2-yl)methanol

There total 1 articles about diphenyl-((2S,4R)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yl-oxy)ethyl]benzyloxy}pyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-[1-(4-iodomethylphenyl)ethoxy]-2,2,6,6-tetramethylpiperidine (845728-30-5) + (2S,4R)-4-hydroxy-2-(1-hydroxy-1,1-diphenylmethyl)pyrroline-1-carboxylic acid tert-butyl ester (344791-02-2) → diphenyl-((2S,4R)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yl-oxy)ethyl]benzyloxy}pyrrolidin-2-yl)methanol (1061611-27-5)

Guidance literature:

(2S,4R)-4-hydroxy-2-(1-hydroxy-1,1-diphenylmethyl)pyrroline-1-carboxylic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; Reflux;

1-[1-(4-iodomethylphenyl)ethoxy]-2,2,6,6-tetramethylpiperidine; In tetrahydrofuran; mineral oil; at 20 ℃; Reflux;

DOI:10.1055/s-2008-1067146

Reference yield: 69.0%

diphenyl-((2S,4R)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yl-oxy)ethyl]benzyloxy}pyrrolidin-2-yl)methanol (1061611-27-5) + 1-(Trimethylsilyl)imidazole (18156-74-6) → 1-(1-{4-[(3R,5S)-5-(diphenyltrimethylsilyloxymethyl)pyrrolidin-3-yloxymethyl]phenyl}ethoxy)-2,2,6,6-tetramethylpiperidine (1061611-21-9)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1055/s-2008-1067146

upstream raw materials:

1-[1-(4-iodomethylphenyl)ethoxy]-2,2,6,6-tetramethylpiperidine

(2S,4R)-4-hydroxy-2-(1-hydroxy-1,1-diphenylmethyl)pyrroline-1-carboxylic acid tert-butyl ester

Downstream raw materials:

1-(1-{4-[(3R,5S)-5-(diphenyltrimethylsilyloxymethyl)pyrrolidin-3-yloxymethyl]phenyl}ethoxy)-2,2,6,6-tetramethylpiperidine