1-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propynyl]-2(1H)-quinolinone

Base Information

Chemical Name:1-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propynyl]-2(1H)-quinolinone
CAS No.:125030-61-7
Molecular Formula:C₂₇H₁₈ClN₅OS
Molecular Weight:495.992
Hs Code.:

Synonyms:1-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propynyl]-2(1H)-quinolinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propynyl]-2(1H)-quinolinone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propynyl]-2(1H)-quinolinone

There total 5 articles about 1-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propynyl]-2(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 67860-41-7
4-(2-chlorophenyl)2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

: 35227-94-2
1-prop-2-ynyl-1H-quinolin-2-one

: 125030-61-7
1-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propynyl]-2(1H)-quinolinone

Guidance literature:: With copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.1021/jm00107a048

Reference yield:

: 59-31-4,70254-42-1,493-62-9
2-quinolone

: 125030-61-7
1-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propynyl]-2(1H)-quinolinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) t-BuOK / 1.) DMF, 10 min, 2.) RT, 30 min

2: 23 percent / PPh₃, CuI, Et₃N, palladium acetate / dimethylformamide / 72 h / Ambient temperature

With copper(l) iodide; potassium tert-butylate; palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00107a048

Reference yield:

: 67860-47-3
5-(2-chlorophenyl)-1,3-dihydro-7-iodo-2H-thieno<2,3-e><1,4>diazepin-2-thione

: 125030-61-7
1-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propynyl]-2(1H)-quinolinone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine / tetrahydrofuran / 0.5 h / Ambient temperature

2: 74.5 percent / p-TSA / ethyl acetate / 0.5 h / Heating

3: 23 percent / PPh₃, CuI, Et₃N, palladium acetate / dimethylformamide / 72 h / Ambient temperature

With copper(l) iodide; palladium diacetate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; hydrazine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00107a048