Technology Process of Nα-diphenylphosphinoylvalylphenylalanine amide
There total 8 articles about Nα-diphenylphosphinoylvalylphenylalanine amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 83 percent / DCCI, ammonium salt of hydroxybenzotriazole / CH2Cl2 / Ambient temperature
2: 96 percent / H2 / 10percent Pd/C / dimethylformamide / 18 h / Ambient temperature
3: CH2Cl2; dimethylformamide / 0.67 h / 0 °C
With
ammonium salt of hydroxybenzotriazole; hydrogen; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 75 percent / 4M aq. NaOH, 1M aq. NaHCO3 / 18 h / Ambient temperature
2: 83 percent / DCCI, ammonium salt of hydroxybenzotriazole / CH2Cl2 / Ambient temperature
3: 96 percent / H2 / 10percent Pd/C / dimethylformamide / 18 h / Ambient temperature
4: CH2Cl2; dimethylformamide / 0.67 h / 0 °C
With
sodium hydroxide; ammonium salt of hydroxybenzotriazole; hydrogen; sodium hydrogencarbonate; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 96 percent / H2 / 10percent Pd/C / dimethylformamide / 18 h / Ambient temperature
2: CH2Cl2; dimethylformamide / 0.67 h / 0 °C
With
hydrogen;
palladium on activated charcoal;
In
dichloromethane; N,N-dimethyl-formamide;
